Gene: ME3
Official Full Name: malic enzyme 3provided by HGNC
Gene Summary: Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31449 | ME3 Knockout cell line (HeLa) | Human | ME3 | 1:3~1:6 | Negative | Online Inquiry |
KO31450 | ME3 Knockout cell line (A549) | Human | ME3 | 1:3~1:4 | Negative | Online Inquiry |
ME3 Gene Knockout Cell Lines represent a groundbreaking tool in genetic research, specifically designed to study the functional roles of the ME3 gene in various biological processes. These cell lines utilize CRISPR-Cas9 gene-editing technology to create precise disruptions in the ME3 gene, allowing scientists to investigate its impact on cellular function, metabolism, and disease mechanisms. By enabling targeted gene disruption, these knockout cell lines facilitate a deeper understanding of gene function and the molecular pathways in which ME3 is involved.
The key function of ME3 Gene Knockout Cell Lines lies in their ability to simulate gene loss-of-function scenarios, which are pivotal in elucidating the roles of specific genes in health and disease. Through rigorous assays, researchers can assess changes in cellular behavior, metabolic profiles, and gene expression patterns resulting from the knockout, leading to insights that could translate into therapeutic developments or novel treatment strategies in areas such as cancer and metabolic disorders.
In terms of scientific importance, the applications of ME3 Gene Knockout Cell Lines are vast, spanning basic research in pharmacology, toxicology, and developmental biology to clinical translations. They provide a robust platform for drug discovery and validation, enabling the identification of potential drug targets that modulate the activity of the ME3 gene or its associated pathways.
Compared to existing alternatives, ME3 Gene Knockout Cell Lines offer unparalleled specificity and reproducibility due to their precise genetic modifications, minimizing off-target effects often seen with traditional knockout methodologies. Their ease of use, alongside rigorous validation against standard benchmarks, positions them as a highly desirable resource for any laboratory engaged in genetic research.
For researchers, clinicians, and biopharmaceutical companies, the value of ME3 Gene Knockout Cell Lines is clear: they provide a powerful means of elucidating gene function while paving the way for the development of innovative solutions in health care. Our company, with its commitment to advancing genetic research and collaboration with leading scientific institutions, proudly offers these exceptional tools to enhance your research capabilities and drive advancements in biological science.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.