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MCOLN1 Knockout Cell Lines

Gene: MCOLN1

Official Full Name: mucolipin TRP cation channel 1provided by HGNC

Gene Summary: This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00129 MCOLN1 Knockout cell line (T98G) Human MCOLN1 1:2-1:4 Negative Online Inquiry
KO01038 MCOLN1 Knockout cell line (HeLa) Human MCOLN1 1:3~1:6 Negative Online Inquiry
KO08021 MCOLN1 Knockout cell line (HCT 116) Human MCOLN1 1:2~1:4 Negative Online Inquiry
KO08022 MCOLN1 Knockout cell line (HEK293) Human MCOLN1 1:3~1:6 Negative Online Inquiry
KO08023 MCOLN1 Knockout cell line (A549) Human MCOLN1 1:3~1:4 Negative Online Inquiry

Background

MCOLN1 Gene Knockout Cell Lines are genetically modified cell lines in which the MCOLN1 gene, responsible for encoding the mucolipin-1 protein, has been deliberately inactivated. This specific genetic alteration allows researchers to explore the biological functions of the gene and its protein product, as well as the implications of its loss on cellular homeostasis and various physiological processes. MCOLN1 plays a crucial role in lysosomal function and calcium signaling, making these knockout cell lines invaluable for studying lysosomal storage disorders and related pathologies.

The key mechanism facilitated by MCOLN1 knockout cell lines involves the disruption of normal lysosomal ion transport, which in turn affects cellular signaling pathways and lipid metabolism. By studying these knockout models, scientists can elucidate the role of mucolipin-1 in diseases like mucolipidosis and pave the way for novel therapeutic strategies. These cell lines are particularly significant for drug discovery and development as they provide a reliable platform for screening potential treatments targeting lysosomal dysfunction.

One of the primary advantages of using MCOLN1 Gene Knockout Cell Lines is their ability to mimic disease states more accurately than wild-type counterparts, which enhances the relevance of experimental findings. Additionally, these cell lines come with validated background checks and extensive supporting data, offering researchers confidence in their results.

This product is invaluable to researchers and clinicians focused on understanding the pathology of lysosomal disorders and developing treatments that can address these complex biological challenges. The MCOLN1 Gene Knockout Cell Lines provide an essential tool for advancing scientific knowledge and therapeutic innovation.

Our company specializes in high-quality genetic models and has a dedicated team committed to supporting cutting-edge research in the field of molecular biology. By choosing our MCOLN1 Gene Knockout Cell Lines, you are investing in a scientifically robust product backed by our expertise and commitment to excellence in research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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