Gene: MCCC2
Official Full Name: methylcrotonyl-CoA carboxylase subunit 2provided by HGNC
Gene Summary: This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16298 | MCCC2 Knockout cell line (HeLa) | Human | MCCC2 | 1:3~1:6 | Negative | Online Inquiry |
KO16299 | MCCC2 Knockout cell line (HCT 116) | Human | MCCC2 | 1:2~1:4 | Negative | Online Inquiry |
KO16300 | MCCC2 Knockout cell line (HEK293) | Human | MCCC2 | 1:3~1:6 | Negative | Online Inquiry |
KO16301 | MCCC2 Knockout cell line (A549) | Human | MCCC2 | 1:3~1:4 | Negative | Online Inquiry |
MCCC2 Gene Knockout Cell Lines are genetically engineered cell lines in which the MCCC2 gene, implicated in mitochondrial fatty acid metabolism, has been precisely disrupted. This knockout allows researchers to study the functional role of the MCCC2 gene in cellular processes such as energy production, metabolic regulation, and disease pathogenesis. By eliminating the expression of MCCC2, these cell lines serve as a critical tool for investigating the gene's contributions to disorders associated with mitochondrial dysfunction.
The key mechanism operating within MCCC2 Knockout Cell Lines involves the alteration of metabolic pathways that depend on the MCCC2 gene's function. Since MCCC2 is important for the catabolism of branched-chain fatty acids, its knockout results in altered lipid metabolism, providing insights into metabolic diseases, insulin resistance, and overall mitochondrial health. Researchers can utilize these knockout models to dissect the molecular mechanisms of diseases like obesity and diabetes, potentially paving the way for novel therapeutic strategies.
The scientific importance of MCCC2 Knockout Cell Lines extends into both research and clinical applications. In the laboratory setting, these cell lines enable high-throughput screening of compounds that may restore metabolic function or modulate pathways impacted by MCCC2 deficiency. Clinically, understanding the effects of MCCC2 gene disruption can aid in the development of targeted therapies for mitochondrial disorders.
Compared to alternative models such as wild-type cell lines or traditional knockout models, MCCC2 Gene Knockout Cell Lines offer unparalleled specificity and reliability. They are generated using CRISPR-Cas9 technology, ensuring precise gene editing and a reproducible phenotype, which reduces variability in experimental outcomes.
The value of MCCC2 Gene Knockout Cell Lines lies in their ability to provide researchers and clinicians with a deeper understanding of metabolic pathways that govern health and disease. With our extensive expertise in genetic engineering and cell line development, our company is committed to offering high-quality biological products that empower scientific advancements in metabolic research and beyond.
Please note that all services are for research use only. Not intended for any clinical use.
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