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MCCC1 Knockout Cell Lines

Gene: MCCC1

Official Full Name: methylcrotonyl-CoA carboxylase subunit 1provided by HGNC

Gene Summary: This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16302 MCCC1 Knockout cell line (HeLa) Human MCCC1 1:3~1:6 Negative Online Inquiry
KO16303 MCCC1 Knockout cell line (HCT 116) Human MCCC1 1:2~1:4 Negative Online Inquiry
KO16304 MCCC1 Knockout cell line (HEK293) Human MCCC1 1:3~1:6 Negative Online Inquiry
KO16305 MCCC1 Knockout cell line (A549) Human MCCC1 1:3~1:4 Negative Online Inquiry

Background

MCCC1 Gene Knockout Cell Lines are precisely engineered cellular models designed to elucidate the functional roles of the MCCC1 gene in various biological processes. These cell lines are created through advanced CRISPR-Cas9 genome editing techniques, which effectively disrupt the MCCC1 gene, allowing researchers to study the downstream effects of its loss on cellular metabolism, proliferation, and differentiation. MCCC1, a crucial enzyme involved in the mitochondrial pathway of branched-chain amino acid metabolism, has implications in metabolic disorders and cancer, making its study vital for both basic and applied research.

The fundamental mechanism of these knockout cell lines involves the introduction of a targeted double-strand break in the genomic DNA of the MCCC1 locus, followed by cellular repair processes that result in gene disruption. This alteration enables researchers to examine the biochemical pathways influenced by MCCC1, thereby shedding light on its role in metabolic pathways and pathological conditions.

The scientific significance of MCCC1 Gene Knockout Cell Lines lies in their diverse applications, ranging from basic research to clinical investigations. They serve as valuable tools in drug development, allowing for the identification of potential therapeutic targets. In addition, these cell lines can facilitate the understanding of disease mechanisms associated with aberrant metabolism, offering insights into therapeutic strategies for metabolic disorders.

One key advantage of our MCCC1 Gene Knockout Cell Lines over alternative models is their robustness and reliability. Unlike transient knockdown methods, these stable cell lines provide consistent and reproducible results, essential for high-throughput screening and longitudinal studies. Additionally, our product is backed by extensive validation studies, ensuring that researchers can trust the integrity of their findings.

In conclusion, MCCC1 Gene Knockout Cell Lines represent a critical resource for researchers and clinicians aiming to investigate metabolic pathways and their implications in human health. With a commitment to advancing scientific discovery, our company is at the forefront of producing high-quality biological products, equipping the scientific community with the tools necessary for groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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