Gene: MCAT
Official Full Name: malonyl-CoA-acyl carrier protein transacylaseprovided by HGNC
Gene Summary: The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27612 | MCAT Knockout cell line (HeLa) | Human | MCAT | 1:3~1:6 | Negative | Online Inquiry |
KO27613 | MCAT Knockout cell line (HCT 116) | Human | MCAT | 1:2~1:4 | Negative | Online Inquiry |
KO27614 | MCAT Knockout cell line (HEK293) | Human | MCAT | 1:3~1:6 | Negative | Online Inquiry |
KO27615 | MCAT Knockout cell line (A549) | Human | MCAT | 1:3~1:4 | Negative | Online Inquiry |
MCAT Gene Knockout Cell Lines are specialized cellular models engineered through targeted genome editing to produce a complete and precise inactivation of the MCAT gene. These tools are invaluable for studying the biological consequences of MCAT deficiency, particularly in metabolic processes and cellular respiration mechanisms. The knockout of this gene allows for the elucidation of its role in critical biological pathways, offering insights that can lead to advancements in both basic and translational research.
The mechanism involves the utilization of technologies such as CRISPR-Cas9 or homologous recombination, which enable researchers to selectively disrupt the MCAT gene without affecting adjacent genomic sequences. This specificity enhances the reliability of results derived from experiments conducted with these cell lines. The MCAT gene is known to be integral in mitochondrial fatty acid metabolism, and its knockout enables the study of implications on energy production and related metabolic disorders.
From a scientific perspective, these cell lines are essential for research involving mitochondrial dysfunction, diabetes, obesity, and other metabolic syndromes. Their applications extend into drug development, where understanding the metabolic pathways can lead to the creation of more effective therapeutic strategies. Additionally, they serve as a model for investigating gene-environment interactions and drug responses.
One key advantage of MCAT Gene Knockout Cell Lines over conventional methods, such as overexpressing or silencing the gene, lies in the simplicity and precision of creating a complete knockout. Researchers benefit from the elimination of compensatory pathways that may confound data in other experimental setups, thus providing clearer and more interpretable results.
For researchers, clinicians, and biopharmaceutical companies, the value of these cell lines lies in their ability to facilitate groundbreaking discoveries in metabolic research and the development of targeted therapies. By choosing our MCAT Gene Knockout Cell Lines, users access rigorously validated models that are supported by our extensive expertise in cell line development and genetic engineering. Our commitment to quality and scientific integrity ensures that these cell lines provide a dependable foundation for innovative research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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