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MBTPS2 Knockout Cell Lines

Gene: MBTPS2

Official Full Name: membrane bound transcription factor peptidase, site 2provided by HGNC

Gene Summary: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06419 MBTPS2 Knockout cell line (HeLa) Human MBTPS2 1:3~1:6 Negative Online Inquiry
KO06420 MBTPS2 Knockout cell line (HCT 116) Human MBTPS2 1:2~1:4 Negative Online Inquiry
KO06421 MBTPS2 Knockout cell line (HEK293) Human MBTPS2 1:3~1:6 Negative Online Inquiry
KO06422 MBTPS2 Knockout cell line (A549) Human MBTPS2 1:3~1:4 Negative Online Inquiry

Background

MBTPS2 Gene Knockout Cell Lines represent a pivotal advancement in cellular and molecular biology, specifically designed to elucidate the functions of the MBTPS2 gene and its implications in various physiological and pathological processes. These genetically modified cell lines have been engineered via CRISPR/Cas9 technology to disable the MBTPS2 gene, leading to a controlled and reproducible disruption of its normal biological activities. By creating a model system where MBTPS2 is absent, researchers can explore the gene's role in cellular homeostasis, stress responses, and its involvement in diseases such as Alzheimer's and certain congenital disorders.

The unique mechanism of these knockout cell lines allows for the examination of important cellular pathways impacted by MBTPS2. By studying the altered phenotypes, researchers can identify downstream molecular changes, contributing to a deeper understanding of the gene's regulation within the context of protein folding and trafficking within the endoplasmic reticulum. This insights contribute to a broader understanding of the interconnectedness of gene products and their roles in cellular function, which is crucial for developing targeted therapies.

One of the critical advantages of MBTPS2 Gene Knockout Cell Lines is their specificity and reliability compared to traditional methods such as pharmacological inhibitors or RNA interference—which often lack the precision required for conclusive studies. These knockout models provide researchers with a stable, homogenous cell line that allows for reproducible experimental results and thus significantly improves data reliability.

Furthermore, for clinicians and researchers in pharmaceutical development, these cell lines enable preclinical models that can facilitate drug discovery and validation of therapeutic strategies targeting MBTPS2-associated pathways. The ability to rapidly create and screen the effects of potential pharmacological agents in a controlled environment will enhance translational research efforts.

Our company specializes in cutting-edge gene editing technologies and provides high-quality biological products that empower researchers in their quest for scientific breakthroughs. With our MBTPS2 Gene Knockout Cell Lines, we aim to enhance the understanding of critical genetic functions and contribute to advancements in therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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