Gene: MAP2K3
Official Full Name: mitogen-activated protein kinase kinase 3provided by HGNC
Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10721 | MAP2K3 Knockout cell line (HeLa) | Human | MAP2K3 | 1:3~1:6 | Negative | Online Inquiry |
KO10722 | MAP2K3 Knockout cell line (HCT 116) | Human | MAP2K3 | 1:2~1:4 | Negative | Online Inquiry |
KO10723 | MAP2K3 Knockout cell line (HEK293) | Human | MAP2K3 | 1:3~1:6 | Negative | Online Inquiry |
KO10724 | MAP2K3 Knockout cell line (A549) | Human | MAP2K3 | 1:3~1:4 | Negative | Online Inquiry |
MAP2K3 Gene Knockout Cell Lines represent a specialized category of biological tools designed for the study of MAP2K3 (Mitogen-activated protein kinase kinase 3), a critical component of the MAPK signaling pathway. These cell lines involve the targeted disruption of the MAP2K3 gene, allowing researchers to investigate gene function and its implications in various cellular processes. By utilizing CRISPR-Cas9 or other gene-editing technologies, these knockout lines create an environment devoid of MAP2K3, which aids in understanding its role in signal transduction, cell proliferation, and apoptosis.
The primary function of these cell lines is to elucidate the biological pathways and molecular mechanisms by which MAP2K3 contributes to cellular responses to extracellular signals. In the absence of MAP2K3, researchers can study alterations in downstream signaling cascades, thereby gaining insights into the gene's effects on physiological processes and pathologies, including cancer and neurodegenerative diseases. This molecular tool is indispensable for high-resolution studies of gene function and is applicable across basic research, drug discovery, and the development of targeted therapies.
What sets our MAP2K3 Gene Knockout Cell Lines apart from alternative models is their high specificity, validated efficiency, and reproducibility. Unlike traditional methods, which may yield off-target effects or phenotypic variability, our knockout lines are generated following rigorous validation protocols to ensure precise gene editing. This precision enables researchers to achieve reliable experimental outcomes and aids in the extrapolation of results to clinical applications.
The value of MAP2K3 Gene Knockout Cell Lines lies in their ability to enhance understanding of both basic biological processes and disease mechanisms, providing a foundation for the development of therapeutic strategies. Clinicians and researchers engaged in signaling pathway studies will find these cell lines invaluable for their capacity to accelerate discovery and innovation in the field.
As a leader in the development of advanced biological products, our company leverages cutting-edge technology and extensive expertise in molecular genetics to provide high-quality, reliable cell line models. With a commitment to advancing scientific research, we equip scientists with the essential tools needed to explore the complexities of genetic function and disease pathology.
Please note that all services are for research use only. Not intended for any clinical use.
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