Gene: MAGT1
Official Full Name: magnesium transporter 1provided by HGNC
Gene Summary: This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25253 | MAGT1 Knockout cell line (HeLa) | Human | MAGT1 | 1:3~1:6 | Negative | Online Inquiry |
KO25254 | MAGT1 Knockout cell line (HCT 116) | Human | MAGT1 | 1:2~1:4 | Negative | Online Inquiry |
KO25255 | MAGT1 Knockout cell line (HEK293) | Human | MAGT1 | 1:3~1:6 | Negative | Online Inquiry |
KO25256 | MAGT1 Knockout cell line (A549) | Human | MAGT1 | 1:3~1:4 | Negative | Online Inquiry |
MAGT1 Gene Knockout Cell Lines are specialized biological tools designed for the functional study of magnesium transport and homeostasis in cellular systems. These cell lines have undergone precise genetic modification to abrogate the expression of the MAGT1 gene, which encodes for a crucial magnesium transporter implicated in various cellular processes, including signal transduction and ion homeostasis. By eliminating MAGT1 expression, researchers can effectively investigate the cellular and systemic impacts of altered magnesium levels, offering insights into a variety of physiological and pathological conditions.
The primary function of MAGT1 Gene Knockout Cell Lines lies in their ability to provide a controlled environment for studying magnesium's roles in cellular metabolism and its implications in diseases such as immunological disorders and cardiovascular diseases. By utilizing these knockout models, scientists can explore the underlying mechanisms of magnesium deficiency, assess the cellular response to oxidative stress, and identify potential pathways for targeted therapies. These models enable the observation of cellular responses without the confounding presence of MAGT1, making them invaluable for dissecting the complexities of magnesium biology.
In terms of scientific significance, MAGT1 Gene Knockout Cell Lines contribute critical insights relevant to both basic research and clinical applications. They serve as vital platforms for drug screening and toxicity assessment related to magnesium dysregulation, advancing our understanding of various health conditions. Comparatively, these cell lines offer a more direct approach than transient knockdown methods, which may not provide stable or long-term insights into gene function, ensuring reproducibility and reliability in experimental outcomes.
What sets MAGT1 Gene Knockout Cell Lines apart from traditional models is their specificity and robustness; they are engineered to embody the knockout status faithfully, offering researchers superior control over their experimental conditions. Moreover, their accessibility for key applications in molecular and cellular biology provides a unique advantage for labs dedicated to elucidating the role of magnesium in health and disease.
In conclusion, MAGT1 Gene Knockout Cell Lines stand as a premier resource for researchers and clinicians aiming to explore the intricate relationship between magnesium and human health. We take pride in our expertise in the development of genetically modified cell lines, ensuring that our products meet the highest standards of scientific integrity, reliability, and innovation for the advancement of biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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