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Lgr4 Knockout Cell Lines

Gene: Lgr4

Official Full Name: leucine-rich repeat-containing G protein-coupled receptor 4provided by MGI

Gene Summary: Enables transmembrane signaling receptor activity. Involved in several processes, including metanephric nephron development; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Located in plasma membrane. Is expressed in several structures, including alimentary system; eye; integumental system; metanephros; and telencephalon. Used to study glaucoma. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00519 Lgr4 gRNA3-gRNA4 KO plasmid Lgr4 $850
KO01180 Lgr4 Knockout cell line(RAW 264.7) Mouse Lgr4 1:2-1:3 Negative Online Inquiry

Background

Lgr4 Gene Knockout Cell Lines are genetically engineered cellular systems that have had the Lgr4 gene selectively inactivated. These cell lines serve as invaluable tools for studying the physiological and pathological roles of Lgr4, which encodes a member of the leucine-rich repeat-containing G protein-coupled receptor family. The knockout of this gene facilitates the exploration of its functions in various biological processes, including cell proliferation, differentiation, and signaling pathways that are pivotal in developmental biology and disease states, particularly in cancer and metabolic disorders.

The core function of Lgr4 Gene Knockout Cell Lines is to provide a controlled environment in which researchers can manipulate and observe the effects of Lgr4 deficiency. By disrupting this gene, scientists can elucidate its role in cellular context, allowing for a deeper understanding of underlying molecular mechanisms. This can lead to insights into how aberrations in Lgr4 contribute to diseases, potentially informing the development of targeted therapies.

The scientific importance of these cell lines cannot be overstated; they are instrumental in research settings aiming to unravel complex genetic networks and can be used in drug discovery processes to identify novel therapeutic targets. In clinical applications, understanding Lgr4’s role may aid the creation of innovative treatments for conditions such as obesity and cancer, where this receptor has demonstrated involvement.

Compared to alternative gene knockout models, our Lgr4 Gene Knockout Cell Lines are rigorously validated for enhanced specificity and consistent performance, ensuring reproducibility in experimental outcomes. They are also accompanied by comprehensive support documentation, including detailed methodologies and experimental guides, which simplifies integration into existing research protocols.

For researchers and clinicians, utilizing Lgr4 Gene Knockout Cell Lines translates into the ability to generate high-quality and reliable data, ultimately accelerating the pace of discovery. Our company prides itself on its expertise in genetic engineering and cell line development, providing cutting-edge tools that empower scientists to make breakthroughs in their respective fields. Our commitment to quality and innovation supports your research objectives and enhances your capacity to deliver impactful results.

Please note that all services are for research use only. Not intended for any clinical use.

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