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LYZ Knockout Cell Lines

Gene: LYZ

Official Full Name: lysozymeprovided by HGNC

Gene Summary: This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36755 LYZ Knockout cell line (HCT 116) Human LYZ 1:2~1:4 Negative Online Inquiry

Background

LYZ Gene Knockout Cell Lines are genetically modified cellular models designed to eliminate the expression of the lysozyme gene (LYZ), a critical component in innate immunity and host defense mechanisms. These cell lines enable researchers to investigate the functional roles of lysozyme in various biological processes, such as antibacterial activity, inflammation, and tissue homeostasis. By employing CRISPR-Cas9 or similar gene editing technologies, these knockout models provide a streamlined approach to studying phenotype changes resulting from gene disruption, facilitating deeper insights into lysozyme's contributions to disease pathology and immune response.

The key functions of LYZ Gene Knockout Cell Lines revolve around their utility in dissecting the cellular and molecular pathways influenced by lysozyme. The absence of lysozyme allows for the assessment of compensatory mechanisms and alternative pathways that may be activated in its absence, thus offering a clearer picture of cellular physiology. This functional understanding is particularly valuable in research settings focusing on infection, autoimmune disorders, and cancer, where the role of immune mediators is crucial.

The scientific importance of these cell lines extends to both basic and translational research environments. In basic research, understanding the knockout phenotype enhances knowledge on gene function, while in clinical settings, these cell lines can serve as platforms for drug development and therapeutic testing, contributing to personalized medicine approaches.

One of the standout advantages of using LYZ Gene Knockout Cell Lines is their specificity and reliability. Unlike other models, such as siRNA knockdowns or traditional knockout mice, these cell lines provide a stable and reproducible system to study the direct consequences of lysozyme absence. This precision reduces variability in experiments and enhances the reliability of results, making them a valuable tool for researchers striving for replicable outcomes in their work.

The uniqueness of these cell lines makes them particularly appealing to researchers and clinicians aiming to solve pressing questions in the field of immunology and beyond. By providing direct insights into the role of lysozyme in cellular responses and disease mechanisms, these knockout models stand to advance scientific knowledge while fostering the development of innovative therapeutic strategies.

Our company prides itself on its expertise in cell line development and genetic engineering technologies. With a commitment to providing researchers with high-quality, reliable tools, our LYZ Gene Knockout Cell Lines represent the pinnacle of innovation and precision in genetic research. Let us support your scientific endeavors with our superior biological product offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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