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LTA4H Knockout Cell Lines

Gene: LTA4H

Official Full Name: leukotriene A4 hydrolaseprovided by HGNC

Gene Summary: The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36768 LTA4H Knockout cell line (HeLa) Human LTA4H 1:3~1:6 Negative Online Inquiry
KO36769 LTA4H Knockout cell line (HCT 116) Human LTA4H 1:2~1:4 Negative Online Inquiry
KO36770 LTA4H Knockout cell line (HEK293) Human LTA4H 1:3~1:6 Negative Online Inquiry
KO36771 LTA4H Knockout cell line (A549) Human LTA4H 1:3~1:4 Negative Online Inquiry

Background

LTA4H Gene Knockout Cell Lines are engineered cell lines that have had the leukotriene A4 hydrolase (LTA4H) gene functionally disrupted, allowing for the study of the biological implications of LTA4H deficiency. This gene plays a critical role in the metabolism of leukotrienes, which are lipid mediators involved in inflammatory responses. By removing the LTA4H gene, these cell lines provide a robust model system to investigate the underlying cellular pathways and physiological changes associated with altered leukotriene production and signaling.

These knockout cell lines serve as powerful tools in research, enabling scientists to elucidate the mechanistic role of LTA4H in various diseases, including asthma, cardiovascular diseases, and other inflammatory conditions. By comparing them with wild-type cell lines, researchers can observe changes in cell behavior, inflammation markers, and responses to therapeutic interventions, enhancing our understanding of therapeutics targeting the leukotriene pathway.

What sets LTA4H Gene Knockout Cell Lines apart from standard cell lines is their specificity and reliability in simulating LTA4H-related dysfunctions. While traditional models may offer limited insights into the gene's role, our knockout lines eliminate confounding variables, providing clear and direct data on the effects of LTA4H inhibition. Additionally, these cell lines are validated for consistent performance, ensuring that researchers can replicate experiments with confidence.

For researchers and clinicians, these knockout cell lines are invaluable for drug discovery and development, as they facilitate the identification of novel therapeutic targets and the evaluation of pharmacological compounds aimed at modulating the leukotriene pathway. Their availability positions your research at the forefront of current biological science, advancing both fundamental and applied research.

Our company's expertise in developing high-quality gene knockout models positions us as a trusted partner in biomedical research. Each product is backed by a commitment to scientific rigor and innovation, ensuring that our offerings meet the evolving needs of researchers in academia and industry alike.

Please note that all services are for research use only. Not intended for any clinical use.

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