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LRRN2 Knockout Cell Lines

Gene: LRRN2

Official Full Name: leucine rich repeat neuronal 2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31857 LRRN2 Knockout cell line (HeLa) Human LRRN2 1:3~1:6 Negative Online Inquiry
KO31858 LRRN2 Knockout cell line (HCT 116) Human LRRN2 1:2~1:4 Negative Online Inquiry
KO31859 LRRN2 Knockout cell line (A549) Human LRRN2 1:3~1:4 Negative Online Inquiry

Background

LRRN2 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the LRRN2 gene, which plays a critical role in neuronal function and synaptic plasticity. These cell lines offer researchers a powerful tool to study the physiological and pathological implications of LRRN2 deficiency, enabling investigations into neurodegenerative diseases, cognitive disorders, and synaptic impairments.

The key function of LRRN2 Gene Knockout Cell Lines lies in their ability to mimic conditions of LRRN2 loss in cellular models. By eliminating the expression of the LRRN2 gene, these cell lines help elucidate the molecular pathways and interactions that contribute to neuronal health and disease. Researchers can utilize these models to explore alterations in synaptic signaling, gene expression patterns, and cellular responses to various stimuli, providing insights into the mechanisms underlying neurological conditions.

Scientifically, LRRN2 Gene Knockout Cell Lines hold immense importance in both research and clinical settings. They facilitate the exploration of LRRN2's role in neurodevelopment and its contributions to disorders such as Alzheimer's disease, schizophrenia, and autism spectrum disorders. With the rise of precision medicine, understanding the genetic underpinnings of these conditions is critical for developing targeted therapies.

Compared to traditional cell lines, LRRN2 Gene Knockout Cell Lines offer unique advantages, including a precise deletion of the LRRN2 gene and the ability to assess its functional outcomes in a controlled environment. This specificity allows for more reliable experimental data and reproducibility than models that employ pharmacological inhibition or non-specific gene silencing techniques.

For researchers and clinicians dedicated to advancing neurological research, these knockout cell lines represent a valuable asset. They provide a definitive resource for understanding salient phenomena related to LRRN2 through a robust and controlled system.

Our company specializes in developing cutting-edge biological products, leveraging advanced genetic engineering techniques to provide high-quality models that accelerate research and therapeutic development. We are committed to aiding scientific discoveries that improve human health and understanding of complex disease mechanisms.

Please note that all services are for research use only. Not intended for any clinical use.

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