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LRRC8B Knockout Cell Lines

Gene: LRRC8B

Official Full Name: leucine rich repeat containing 8 VRAC subunit Bprovided by HGNC

Gene Summary: Contributes to volume-sensitive anion channel activity. Involved in monoatomic anion transmembrane transport. Located in cytoplasm and plasma membrane. Part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29227 LRRC8B Knockout cell line (HeLa) Human LRRC8B 1:3~1:6 Negative Online Inquiry
KO29228 LRRC8B Knockout cell line (HCT 116) Human LRRC8B 1:2~1:4 Negative Online Inquiry
KO29229 LRRC8B Knockout cell line (HEK293) Human LRRC8B 1:3~1:6 Negative Online Inquiry
KO29230 LRRC8B Knockout cell line (A549) Human LRRC8B 1:3~1:4 Negative Online Inquiry

Background

LRRC8B Gene Knockout Cell Lines are precisely engineered cellular models designed to study the function and regulation of the LRRC8B gene, which plays a critical role in the formation of volume-regulated anion channels (VRACs) in various cellular processes. These knockout cell lines offer a unique platform for investigating the physiological and pathological roles of LRRC8B by enabling researchers to observe the cellular responses resulting from the absence of this specific gene.

The primary mechanism by which LRRC8B exerts its influence involves the modulation of anion currents and cellular ion homeostasis, which have significant implications in processes such as cell volume regulation, apoptosis, and cellular signaling pathways. By using these knockout cell lines, scientists can elucidate how LRRC8B knockout affects ion transport and contribute to understanding diseases associated with ion channel dysfunction, including certain cancers and neurodegenerative diseases.

In research and clinical settings, the LRRC8B Gene Knockout Cell Lines provide indispensable tools for drug discovery and development. Their application spans from evaluating therapeutic strategies targeting ion channel-related pathways to screening for potential pharmacological agents. Compared to traditional cell models, these knockout lines offer enhanced specificity and relevance, helping to derive more accurate conclusions about the role of LRRC8B in cell biology and disease mechanisms.

What sets LRRC8B Gene Knockout Cell Lines apart from alternative models is the precision of their genome editing, coupled with robust validation protocols that confirm the complete absence of the LRRC8B protein. This high degree of validation ensures that researchers can trust their experimental results, reducing the likelihood of artifacts that might arise from residual gene expression.

The value of LRRC8B Gene Knockout Cell Lines lies in their ability to accelerate scientific discovery by providing researchers and clinicians with critical insights into ion channel function, cellular dynamics, and the therapeutic potential of targeting specific gene pathways. Their clear application in both basic research and translational medicine makes them an invaluable asset for anyone investigating the complexities of cellular regulation.

Our company, dedicated to advancing scientific research through innovative biological products, prides itself on the quality and precision of our genetic models. Explore the possibilities of the LRRC8B Gene Knockout Cell Lines as you continue your pioneering endeavors in understanding cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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