Gene: LPXN
Official Full Name: leupaxinprovided by HGNC
Gene Summary: The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33254 | LPXN Knockout cell line (HeLa) | Human | LPXN | 1:3~1:6 | Negative | Online Inquiry |
KO33255 | LPXN Knockout cell line (HCT 116) | Human | LPXN | 1:2~1:4 | Negative | Online Inquiry |
KO33256 | LPXN Knockout cell line (HEK293) | Human | LPXN | 1:3~1:6 | Negative | Online Inquiry |
KO33257 | LPXN Knockout cell line (A549) | Human | LPXN | 1:3~1:4 | Negative | Online Inquiry |
LPXN Gene Knockout Cell Lines are meticulously engineered cellular models in which the LPXN gene has been inactivated through precise gene editing techniques such as CRISPR/Cas9. These knockout cell lines serve as invaluable tools for studying the biological role of the LPXN gene, which is implicated in various cellular processes, including cytoskeletal dynamics and cellular signaling pathways. By completely silencing the gene, researchers can elucidate the functional consequences of LPXN loss, thereby advancing their understanding of related pathophysiological conditions such as cancer, neurological disorders, and other diseases marked by altered cell behavior.
The primary function of LPXN Gene Knockout Cell Lines lies in their ability to replicate specific mutations, enabling the analysis of signaling cascades and cellular mechanics without the confounding effects of native gene expression. This is particularly crucial in high-throughput screening applications, where consistent and reproducible results are paramount. These cell lines facilitate targeted investigations into gene function and manipulation, allowing researchers to dissect complex pathways involved in cell proliferation, migration, and adhesion.
In the context of scientific importance, LPXN knockout models are pivotal for both academic and clinical research, offering insights that propel drug development and therapeutic strategies aimed at diseases where LPXN plays a significant role. Their ability to provide clarity on gene function underscores their applicability in identifying potential biomarkers for diagnostics and prognostics.
What sets LPXN Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, developed under stringent quality assurance protocols. Each cell line undergoes thorough validation to confirm the absence of LPXN expression, ensuring that experimental outcomes are directly attributable to the knockout status. This precision significantly reduces background noise associated with off-target effects, a common pitfall in less rigorously constructed models.
For researchers and clinicians committed to translating findings into impactful therapies, the use of LPXN Gene Knockout Cell Lines represents a strategic advantage. They provide a robust foundation for groundbreaking research in gene function and drug discovery, directly informing clinical applications and enhancing therapeutic efficacy.
Our company specializes in the development of high-quality genetic models, leveraging state-of-the-art technology and deep expertise in molecular biology. We remain dedicated to equipping researchers with the precise tools needed to accelerate their scientific endeavors and ultimately improve patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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