Gene: LOXL1
Official Full Name: lysyl oxidase like 1provided by HGNC
Gene Summary: This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36791 | LOXL1 Knockout cell line (HeLa) | Human | LOXL1 | 1:3~1:6 | Negative | Online Inquiry |
KO36792 | LOXL1 Knockout cell line (HCT 116) | Human | LOXL1 | 1:2~1:4 | Negative | Online Inquiry |
KO36793 | LOXL1 Knockout cell line (HEK293) | Human | LOXL1 | 1:3~1:6 | Negative | Online Inquiry |
LOXL1 Gene Knockout Cell Lines are an expertly engineered biological resource designed for the study of lysyl oxidase-like 1 (LOXL1), an enzyme that plays a pivotal role in the regulation of collagen and elastin crosslinking. The knockout of the LOXL1 gene enables researchers to investigate the mechanistic functions of this enzyme in various physiological and pathological processes, particularly in areas such as fibrosis, cardiovascular diseases, and tissue repair.
The primary function of LOXL1 involves the oxidative deamination of lysine residues in collagen and elastin, facilitating their crosslinking and hence contributing to the structural integrity of tissues. By utilizing these knockout cell lines, researchers can elucidate the pathways influenced by LOXL1, allowing for a more profound understanding of its role in extracellular matrix dynamics and cell signaling. Such insights are paramount in advancing therapeutic strategies for conditions related to abnormal tissue remodeling.
The scientific importance of LOXL1 Gene Knockout Cell Lines extends to both research and clinical applications, making them invaluable tools in the exploration of disease mechanisms and the development of targeted therapies. Compared to traditional wild-type models, these knockout cell lines offer a unique advantage by providing a clear and precise environment to assess the functional consequences of LOXL1 deficiency.
Moreover, our LOXL1 Gene Knockout Cell Lines are rigorously validated for specificity and reproducibility, ensuring high-quality experimental results. Their ready availability fosters acceleration in research timelines, enabling researchers and clinicians to make significant advancements without the delays often encountered with conventional cell line models.
By choosing our LOXL1 Gene Knockout Cell Lines, users benefit from our company's extensive expertise in developing high-quality biological products. We are committed to enhancing research capabilities and improving patient outcomes through innovative tools; our products stand as a testament to that commitment, driving impactful discoveries in the field of biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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