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LMO1 Knockout Cell Lines

Gene: LMO1

Official Full Name: LIM domain only 1provided by HGNC

Gene Summary: This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36801 LMO1 Knockout cell line (HeLa) Human LMO1 1:3~1:6 Negative Online Inquiry
KO36802 LMO1 Knockout cell line (HEK293) Human LMO1 1:3~1:6 Negative Online Inquiry
KO36803 LMO1 Knockout cell line (A549) Human LMO1 1:3~1:4 Negative Online Inquiry

Background

LMO1 Gene Knockout Cell Lines are specially engineered mammalian cell lines featuring targeted deletions of the LMO1 gene, which encodes a transcriptional regulator implicated in several biological processes, including hematopoiesis and oncogenesis. This product allows researchers to effectively study the role of LMO1 in gene regulation and its contribution to various cellular pathways associated with diseases such as leukemia. By employing CRISPR-Cas9 technology for precise gene editing, the LMO1 Gene Knockout Cell Lines enable knockdown or complete loss of gene function, providing a robust model system for dissecting the molecular mechanisms underlying LMO1's influence in both normal and pathological contexts.

The unique functionality of these knockout cell lines lies in their ability to facilitate high-throughput screening experiments, enabling scientists to investigate how the absence of LMO1 affects cellular responses to external stimuli, drug treatments, or environmental conditions. In research settings, these models are invaluable for elucidating gene networks, identifying actionable targets for therapeutics, and understanding resistance mechanisms in cancers. They are also critical tools for systems biology approaches, helping decipher complex interactions within signaling pathways.

Compared to alternative models, the LMO1 Gene Knockout Cell Lines provide several advantages: they are highly reproducible, yield consistent results, and can be utilized in a variety of assays, including cell viability, proliferation, and migration studies. Moreover, the specificity of the knockout ensures that observed phenotypic changes can be directly attributed to the loss of LMO1 expression, reducing off-target effects common in other methodologies.

Researchers and clinicians will find great value in these cell lines as they open avenues for translational research and therapeutic innovation in oncology and related fields. Ultimately, our company is dedicated to delivering high-quality biological products backed by cutting-edge scientific techniques and rigorous validation processes, ensuring researchers have access to the most reliable tools for advancing their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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