Gene: LIN9
Official Full Name: lin-9 DREAM MuvB core complex componentprovided by HGNC
Gene Summary: This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16538 | LIN9 Knockout cell line (HeLa) | Human | LIN9 | 1:3~1:6 | Negative | Online Inquiry |
KO16539 | LIN9 Knockout cell line (HCT 116) | Human | LIN9 | 1:2~1:4 | Negative | Online Inquiry |
KO16540 | LIN9 Knockout cell line (HEK293) | Human | LIN9 | 1:3~1:6 | Negative | Online Inquiry |
KO16541 | LIN9 Knockout cell line (A549) | Human | LIN9 | 1:3~1:4 | Negative | Online Inquiry |
LIN9 Gene Knockout Cell Lines are a state-of-the-art tool designed to facilitate the study of gene function and the regulation of cellular processes. These cell lines are engineered to specifically disrupt the LIN9 gene, a critical component involved in various signaling pathways, including those associated with cell cycle regulation and differentiation. By knocking out this gene, researchers can meticulously assess its contributions to cellular behavior and the mechanisms underlying disease states, such as cancer and metabolic disorders.
The primary mechanism of action in LIN9 Gene Knockout Cell Lines revolves around targeted gene disruption facilitated by CRISPR/Cas9 technology, ensuring highly efficient and precise gene editing. This advanced method results in stable cell lines that maintain the knockout phenotype across cell divisions, providing a robust platform for longitudinal studies. Researchers can employ these cell lines to explore the downstream effects of LIN9 loss, enabling insights into cellular transitions, gene expression profiles, and potential compensatory mechanisms triggered by the knockout.
The scientific importance of LIN9 Gene Knockout Cell Lines extends beyond basic research; they are invaluable in preclinical studies for drug development and therapeutic target validation. Understanding the role of LIN9 in various biological contexts empowers researchers to identify novel therapeutic strategies for manipulating key pathways implicated in disease progression.
In comparison to conventional methods, such as RNA interference or other knockout approaches, LIN9 Gene Knockout Cell Lines provide several advantages. These lines exhibit more stable gene expression deficits, eliminate off-target effects commonly associated with transient knockdowns, and allow for more comprehensive observations of cellular physiology. Their ability to model physiological conditions more closely sets them apart from other alternatives, thereby enhancing experimental throughput and reproducibility.
For researchers and clinicians, LIN9 Gene Knockout Cell Lines represent a valuable asset among modern biological products. Their ability to generate biologically relevant data supports not only fundamental research but also translational applications that hold promise for advancing medical science. Backed by cutting-edge technology and our company’s extensive expertise in cellular models, LIN9 Gene Knockout Cell Lines are poised to become an essential resource in your research toolkit, promoting rigorous scientific inquiry and facilitating breakthroughs in gene function studies.
Please note that all services are for research use only. Not intended for any clinical use.
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