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LHB Knockout Cell Lines

Gene: LHB

Official Full Name: luteinizing hormone subunit betaprovided by HGNC

Gene Summary: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07596 LHB Knockout cell line (HEK293) Human LHB 1:3~1:6 Negative Online Inquiry

Background

LHB Gene Knockout Cell Lines are genetically engineered cellular models that have had the luteinizing hormone-beta (LHB) gene systematically disrupted. This precise genetic modification allows researchers to investigate the role of LHB in various biological processes, including reproductive function and hormone regulation. By completely knocking out the expression of the LHB gene, these cell lines enable the study of downstream pathways and gene interactions crucial in understanding fertility, hormone-related cancers, and other reproductive disorders.

The primary function of LHB Gene Knockout Cell Lines lies in their ability to mimic conditions of LHB deficiency, providing a powerful tool for dissecting mechanisms of action in various physiological and pathological states. Employing CRISPR-Cas9 or other genome-editing technologies, these cell lines serve as reliable platforms for exploring gene functionality, cellular responses to LHB absence, and screening potential therapeutic agents targeting LHB-related pathways.

In research and clinical settings, LHB Gene Knockout Cell Lines are invaluable for elucidating the mechanisms of hormonal control in reproductive health and disease. Their use extends to drug discovery, toxicology, and therapeutic development, allowing scientists to evaluate how perturbations in LHB signaling can influence disease phenotypes and treatment responses.

Compared to traditional methods such as wild-type cell lines or transgenic models, LHB Gene Knockout Cell Lines provide specificity and reproducibility, minimizing off-target effects and allowing for more straightforward interpretation of results. They facilitate a deeper understanding of gene function and pharmacodynamics, thus enhancing the efficiency of research initiatives.

The value of these cell lines lies in their capacity to empower researchers and clinicians by providing and refining insights into hormonal mechanisms that drive critical reproductive functions and disorders. Their application can lead to breakthroughs in therapeutic interventions, improving patient outcomes in reproductive health.

Our company specializes in delivering high-quality genetic models tailored to meet the rigorous demands of the scientific community, backed by our expertise in gene editing technologies. We are committed to supporting advancements in research and therapeutic development, ensuring that our products facilitate significant contributions to biomedicine.

Please note that all services are for research use only. Not intended for any clinical use.

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