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LCMT1 Knockout Cell Lines

Gene: LCMT1

Official Full Name: leucine carboxyl methyltransferase 1provided by HGNC

Gene Summary: LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22524 LCMT1 Knockout cell line (HeLa) Human LCMT1 1:3~1:6 Negative Online Inquiry
KO22525 LCMT1 Knockout cell line (HCT 116) Human LCMT1 1:2~1:4 Negative Online Inquiry
KO22526 LCMT1 Knockout cell line (HEK293) Human LCMT1 1:3~1:6 Negative Online Inquiry
KO22527 LCMT1 Knockout cell line (A549) Human LCMT1 1:3~1:4 Negative Online Inquiry

Background

The LCMT1 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of protein methylation pathways, specifically targeting the Leucine Carboxyl Methyltransferase 1 (LCMT1) gene. These cell lines have been constructed using CRISPR-Cas9 technology to introduce precise deletions in the LCMT1 gene, providing a powerful tool for researchers to investigate the functional consequences of LCMT1 loss and its implications in various physiological and pathological processes.

The primary function of the LCMT1 Gene Knockout Cell Lines is to enable detailed exploration of LCMT1's role in regulating protein functionality through methylation. In eukaryotic cells, LCMT1 is instrumental in catalyzing protein methylation, a post-translational modification that can affect protein stability, localization, and activity. By employing these knockout lines, researchers can assess how the absence of LCMT1 influences cellular signaling pathways, gene expression, and ultimately, cellular behavior in both normal and disease contexts.

The scientific importance of these cell lines is underscored by their potential applications in a range of research fields, including cancer biology, neurodegenerative diseases, and metabolic disorders. Understanding the mechanistic role of LCMT1 could inform therapeutic strategies and biomarker development for diseases where protein methylation patterns are disrupted. These cell lines serve as robust platforms for high-throughput screening, drug discovery, and translational research aimed at elucidating disease mechanisms.

Unique selling points of LCMT1 Gene Knockout Cell Lines include their ease of use, reproducibility, and compatibility with various assays, including Western blotting, flow cytometry, and live-cell imaging. Researchers benefit from a dedicated model specifically tailored for investigating LCMT1's functions, eliminating variability present in wild-type cell lines often used for such studies. Furthermore, the knockout efficiency is rigorously validated, ensuring high reliability of results.

For researchers and clinicians alike, investing in LCMT1 Gene Knockout Cell Lines represents a significant stride toward deciphering complex cellular mechanisms that underpin numerous diseases. Our company specializes in providing high-quality biological products supported by extensive expertise in genetic engineering techniques. We are committed to advancing scientific discovery by equipping researchers with cutting-edge tools that drive innovative solutions in research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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