Gene: KNDC1
Official Full Name: kinase non-catalytic C-lobe domain containing 1provided by HGNC
Gene Summary: The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24236 | KNDC1 Knockout cell line (HCT 116) | Human | KNDC1 | 1:2~1:4 | Negative | Online Inquiry |
KO24237 | KNDC1 Knockout cell line (A549) | Human | KNDC1 | 1:3~1:4 | Negative | Online Inquiry |
KNDC1 Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate the study of the KNDC1 gene's role in cellular processes. These cell lines are generated using CRISPR-Cas9 technology, a revolutionary genome editing approach that allows for precise disruptions of target genes, providing researchers with a viable model to understand gene function, regulatory mechanisms, and cellular responses associated with KNDC1.
The primary function of KNDC1 Gene Knockout Cell Lines lies in their ability to mimic the absence of KNDC1, enabling researchers to explore a wide range of cellular effects, including implications in signal transduction, cell proliferation, apoptosis, and differentiation pathways. By utilizing these knockout models, scientists can discern the biological significance of KNDC1 in various physiological and pathological contexts, paving the way for novel therapeutic strategies.
The scientific importance of these cell lines extends into both research and clinical applications. In research settings, they serve as critical models for cancer biology, developmental studies, and various disease mechanisms involving cellular stress responses. Clinically, insights gained from understanding KNDC1 can contribute to advancements in personalized medicine, substrate-specific therapies, and potential drug development targeting KNDC1-related pathways.
What sets KNDC1 Gene Knockout Cell Lines apart from alternative gene editing approaches is their inherent reliability and reproducibility, enhancing experimental outcomes. Unlike traditional methods that can face challenges such as off-target effects or incomplete knockouts, our optimized CRISPR-Cas9 approach ensures specific targeting and consistent gene disruption. This precision translates into more accurate data, ultimately leading to greater confidence in therapeutic hypotheses.
For researchers, clinicians, and other target users, the value of KNDC1 Gene Knockout Cell Lines lies in their ability to provide clear and concise insights into gene function, making them indispensable for innovative scientific explorations and therapeutic developments. Our company, with expertise in creating high-quality biological products, is committed to empowering researchers with cutting-edge tools like these, facilitating significant advancements in the understanding of genetic influences in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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