Gene: KLF10
Official Full Name: KLF transcription factor 10provided by HGNC
Gene Summary: This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06177 | KLF10 Knockout cell line (HeLa) | Human | KLF10 | 1:3~1:6 | Negative | Online Inquiry |
KO06178 | KLF10 Knockout cell line (HCT 116) | Human | KLF10 | 1:2~1:4 | Negative | Online Inquiry |
KO06179 | KLF10 Knockout cell line (HEK293) | Human | KLF10 | 1:3~1:6 | Negative | Online Inquiry |
KO06180 | KLF10 Knockout cell line (A549) | Human | KLF10 | 1:3~1:4 | Negative | Online Inquiry |
KLF10 Gene Knockout Cell Lines are specialized cellular models where the KLF10 gene, which encodes the Krüppel-like factor 10 protein, has been precisely disrupted or "knocked out." This innovative biological tool enables researchers to investigate the role of KLF10 in various cellular processes, including differentiation, proliferation, and apoptosis. The knockout mechanism typically employs CRISPR-Cas9 technology, allowing for targeted gene editing that results in the complete absence of KLF10 expression, thus providing a platform for functional studies that elucidate the gene's contribution to both normal and pathological states.
Key functions of KLF10 involve its regulation of gene expression pathways linked to cell cycle control, as well as its role as a transcription factor that influences signaling cascades relevant to cancer biology and metabolic disorders. By utilizing KLF10 Gene Knockout Cell Lines, scientists can systematically dissect the pathways in which KLF10 is involved, paving the way for discovery of novel therapeutic targets.
In research and clinical settings, the scientific importance of these cell lines cannot be overstated. They serve as critical models for understanding diseases where KLF10 may play a pivotal role, such as certain cancers, cardiovascular diseases, and metabolic syndromes. This knowledge facilitates the development of more effective interventions and enhances our understanding of disease mechanisms.
What sets KLF10 Gene Knockout Cell Lines apart from alternative models is their enhanced specificity and effectiveness for studying the direct effects of gene loss. Unlike traditional knockdown methods, which may retain partial gene function, our knockout cell lines provide complete ablation of KLF10, allowing researchers to obtain clearer and more definitive results.
KLF10 Gene Knockout Cell Lines are invaluable to researchers and clinicians endeavoring to connect genetic regulation to phenotypic outcomes. They provide essential insights that enable therapeutic advancements and foster a deeper understanding of complex biological systems. At our company, we are committed to delivering high-quality biological products backed by extensive expertise in gene editing technologies, ensuring that you have reliable tools for your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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