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KIF17 Knockout Cell Lines

Gene: KIF17

Official Full Name: kinesin family member 17provided by HGNC

Gene Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex and cell projection organization. Predicted to act upstream of or within microtubule-based process; protein-containing complex localization; and vesicle-mediated transport. Predicted to be located in cytosol. Predicted to be part of kinesin complex. Predicted to be active in several cellular components, including cilium; microtubule cytoskeleton; and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16725 KIF17 Knockout cell line (HCT 116) Human KIF17 1:2~1:4 Negative Online Inquiry
KO16726 KIF17 Knockout cell line (A549) Human KIF17 1:3~1:4 Negative Online Inquiry

Background

KIF17 Gene Knockout Cell Lines are specialized cellular models generated through advanced genetic engineering techniques, specifically designed to study the functional implications of the KIF17 gene. KIF17 encodes a motor protein that plays a significant role in intracellular transport, particularly related to dendritic development, neuronal signaling, and synaptic function. By knocking out the KIF17 gene, these cell lines provide researchers with a unique opportunity to explore the phenotypic consequences of KIF17 deficiency, enabling the analysis of neural development, synaptic plasticity, and potential links to neurodegenerative conditions.

The key mechanism behind the KIF17 Gene Knockout Cell Lines involves the CRISPR/Cas9 technology, which allows for precise gene editing. This results in the targeted deletion of the KIF17 gene, leading to a lack of its encoded protein. Consequently, researchers can investigate the downstream effects of KIF17 loss on cellular processes, mitochondrial dynamics, and signaling pathways involved in neurobiology and other cellular functions.

The scientific importance of these knockout cell lines is underscored by their applications in both research and therapeutic settings. They serve as crucial tools for elucidating the role of KIF17 in health and disease, facilitating studies into disorders such as Alzheimer's and other neurodegenerative diseases. As researchers strive to uncover novel therapeutic targets, understanding the role of motor proteins like KIF17 becomes imperative.

What sets KIF17 Gene Knockout Cell Lines apart from alternatives includes their high specificity and reproducibility, ensuring that findings are both reliable and translatable. Unlike traditional methods, the precision of CRISPR technology minimizes off-target effects, allowing for clearer interpretations of experimental results.

For researchers and clinicians focused on neuroscience and cellular biology, KIF17 Gene Knockout Cell Lines offer invaluable insights into the molecular underpinnings of cellular processes. With a proven track record in genetic editing technologies, our company is committed to delivering high-quality biological products that empower the scientific community to make significant advancements in understanding human health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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