Home / KIF12 Knockout Cell Lines

KIF12 Knockout Cell Lines

Gene: KIF12

Official Full Name: kinesin family member 12provided by HGNC

Gene Summary: This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. [provided by RefSeq, Jul 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30866 KIF12 Knockout cell line (HCT 116) Human KIF12 1:2~1:4 Negative Online Inquiry
KO30867 KIF12 Knockout cell line (HEK293) Human KIF12 1:3~1:6 Negative Online Inquiry
KO30868 KIF12 Knockout cell line (A549) Human KIF12 1:3~1:4 Negative Online Inquiry

Background

KIF12 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the KIF12 gene, which encodes a member of the kinesin superfamily involved in intracellular transport and mitotic processes. These knockout cell lines provide a powerful tool for researchers to investigate the functional role of KIF12 in cellular dynamics, including its contribution to cell division, transport of organelles, and implications in cancer biology.

The key functions of these cell lines center around the disruption of KIF12-mediated pathways, allowing for the analysis of downstream effects on mitotic spindle organization and chromosome segregation. Through loss-of-function studies, researchers can elucidate the mechanisms by which KIF12 influences cellular health, proliferation, and apoptosis, providing insight into its potential role as a therapeutic target in malignancies where these processes are dysregulated.

The scientific importance of KIF12 Gene Knockout Cell Lines is underscored by their application in both basic research and clinical settings. They facilitate high-throughput screening of drugs and therapeutic compounds aimed at tackling diseases influenced by kinesin family member activities. Moreover, these cell lines enable the dissection of molecular networks and pathways that involve KIF12, contributing to the broader understanding of cellular physiology and potential therapeutic interventions.

Compared to traditional cell lines that express KIF12, the knockout lines uniquely position researchers to observe phenotypic and behavioral changes resultant from the absence of this gene. The specificity of these models enhances experimental reliability, yielding more accurate data that can inform clinical applications.

For researchers and clinicians, the value of KIF12 Gene Knockout Cell Lines lies in their ability to provide robust models for investigating gene function, mechanism of action of drugs, and biological response to therapies. By employing these knockout models, users can gain vital insights that translate into improved treatment strategies for diseases associated with KIF12 dysregulation.

Our company is dedicated to advancing biological research by providing high-quality, precise genetic tools like KIF12 Gene Knockout Cell Lines, supported by our expertise in gene editing technologies and commitment to facilitating groundbreaking research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.