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KDM6A Knockout Cell Lines

Gene: KDM6A

Official Full Name: lysine demethylase 6Aprovided by HGNC

Gene Summary: This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07228 KDM6A Knockout cell line (HeLa) Human KDM6A 1:3~1:6 Negative Online Inquiry
KO07229 KDM6A Knockout cell line (HCT 116) Human KDM6A 1:2~1:4 Negative Online Inquiry
KO07230 KDM6A Knockout cell line (HEK293) Human KDM6A 1:3~1:6 Negative Online Inquiry
KO07231 KDM6A Knockout cell line (A549) Human KDM6A 1:3~1:4 Negative Online Inquiry

Background

KDM6A Gene Knockout Cell Lines represent a significant advancement in the study of epigenetic regulation and gene expression. These cell lines are genetically modified to specifically disrupt the KDM6A gene, which encodes an important histone demethylase involved in the demethylation of histone H3 at lysine 27 (H3K27). By knocking out this gene, researchers can investigate the downstream effects of altered gene expression patterns, providing insights into various cellular processes, including differentiation, proliferation, and responses to environmental stimuli.

The primary function of KDM6A is to catalyze the removal of methyl groups from histones, leading to a more open chromatin structure that is conducive to gene transcription. By utilizing KDM6A Gene Knockout Cell Lines, scientists can explore the mechanistic roles of KDM6A in cancer biology, developmental processes, and stem cell regulation. The ability to study these pathways in a controlled environment allows for a deeper understanding of the epigenetic landscape that governs gene expression.

In research and clinical settings, the importance of KDM6A knockout models lies in their potential to uncover novel therapeutic targets for diseases such as cancer and neurological disorders. The manipulation of the epigenetic framework via KDM6A provides an avenue for tailored therapeutic interventions, enabling personalized medicine approaches that are increasingly relevant in contemporary healthcare.

One of the unique selling points of our KDM6A Gene Knockout Cell Lines is their rigorous validation and consistency, which ensure reproducibility and reliability in experimental outcomes—an essential criterion for researchers striving to achieve credible results. In contrast to alternative models that may lack specificity or have variable backgrounds, our cell lines embody a robust system for precise gene function assessment.

Researchers and clinicians alike will find the KDM6A Gene Knockout Cell Lines valuable for their ability to facilitate groundbreaking studies in gene expression regulation and epigenetics, thus advancing the goals of discovery and innovation across various biological disciplines. Additionally, our company brings extensive expertise in genetic engineering and cell line development, ensuring that you receive high-quality products that support your research objectives effectively. We are committed to providing robust scientific tools that empower your research endeavors in understanding complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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