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KDM5C Knockout Cell Lines

Gene: KDM5C

Official Full Name: lysine demethylase 5Cprovided by HGNC

Gene Summary: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04331 KDM5C Knockout cell line (HeLa) Human KDM5C 1:3~1:6 Negative Online Inquiry
KO04332 KDM5C Knockout cell line (HCT 116) Human KDM5C 1:2~1:4 Negative Online Inquiry
KO04333 KDM5C Knockout cell line (HEK293) Human KDM5C 1:3~1:6 Negative Online Inquiry
KO04334 KDM5C Knockout cell line (A549) Human KDM5C 1:3~1:4 Negative Online Inquiry

Background

KDM5C Gene Knockout Cell Lines are genetically modified cellular models developed to facilitate in-depth research into the functional roles of the KDM5C gene, which encodes a member of the Jumonji C-domain containing family of histone demethylases. These cell lines are engineered to have a complete knockout of the KDM5C gene, allowing researchers to study the consequences of its absence on various cellular processes, including gene regulation, cell proliferation, and differentiation.

The primary mechanism of action involves understanding how the KDM5C gene contributes to the demethylation of specific lysine residues on histones, which is critical for the modulation of chromatin structure and gene expression. By utilizing these knockout cell lines, scientists can elucidate the pathways in which KDM5C is involved, including cancer biology, neurodevelopmental disorders, and cellular stress response mechanisms.

The scientific importance of KDM5C Gene Knockout Cell Lines extends to their application in both basic research and translational studies. They serve as pivotal tools for exploring gene function, thereby aiding in the identification of novel therapeutic targets and biomarkers. Moreover, these cell lines can be employed in drug discovery processes to assess the efficacy of compounds specifically targeting histone demethylation pathways.

Compared to alternative cell models, the KDM5C Gene Knockout Cell Lines offer unique advantages such as complete gene inactivation, which ensures that any observed phenotypic changes can be directly attributed to the absence of KDM5C. This provides a clearer understanding of its biological role compared to partial knockdowns or overexpression strategies.

For researchers and clinicians, the value of KDM5C Gene Knockout Cell Lines lies in their ability to drive forward innovative research and accelerate the development of targeted therapies. These cell lines not only enrich the existing repository of genetic models but also represent a critical resource for understanding complex genetic interactions and their implications in health and disease.

Our company specializes in the development and supply of high-quality cellular models and genetic tools. With a commitment to scientific advancement, we are dedicated to providing researchers with the resources they need to make significant breakthroughs in their work.

Please note that all services are for research use only. Not intended for any clinical use.

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