Gene: KDM3B
Official Full Name: lysine demethylase 3Bprovided by HGNC
Gene Summary: Predicted to enable chromatin DNA binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of acute lymphoblastic leukemia; breast cancer; colorectal cancer; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22204 | KDM3B Knockout cell line (HeLa) | Human | KDM3B | 1:3~1:6 | Negative | Online Inquiry |
KO22205 | KDM3B Knockout cell line (HCT 116) | Human | KDM3B | 1:2~1:4 | Negative | Online Inquiry |
KO22206 | KDM3B Knockout cell line (HEK293) | Human | KDM3B | 1:3~1:6 | Negative | Online Inquiry |
KO22207 | KDM3B Knockout cell line (A549) | Human | KDM3B | 1:3~1:4 | Negative | Online Inquiry |
KDM3B Gene Knockout Cell Lines are highly specialized biological tools designed for the study of gene function and regulation, specifically targeting the KDM3B gene, which encodes for a histone demethylase involved in various biological processes such as gene expression, cell differentiation, and cancer progression. These cell lines are engineered through precise genome-editing techniques, allowing researchers to create a loss-of-function model that facilitates the exploration of KDM3B's role in cellular pathways.
The primary function of KDM3B Gene Knockout Cell Lines lies in their ability to enable genetic and phenotypic analyses of KDM3B. By removing the KDM3B gene, researchers can assess changes in cellular behavior, epigenetic modifications, and downstream signaling pathways that may be influenced by its absence. This approach proves invaluable for dissecting complex interactions in cancer biology, developmental biology, and epigenetics, ultimately providing insights into therapeutic targets and biomarkers.
The scientific importance of these cell lines is underscored by their applications in both research and clinical settings. They serve as vital models for studying the role of histone demethylation in normal and pathological states, helping to elucidate mechanisms underlying specific diseases, including various cancers and metabolic disorders. Additionally, these models are crucial in the development of novel therapeutic strategies aimed at modulating epigenetic marks for disease intervention.
KDM3B Gene Knockout Cell Lines present significant advantages over traditional models and commercially available alternatives. Their specificity to the KDM3B gene allows for more precise control over experimental variables, resulting in more consistent and reproducible results. Furthermore, the use of state-of-the-art CRISPR/Cas9 technology ensures the accuracy of the knockouts, minimizing off-target effects and resulting in a more reliable research tool.
For researchers and clinicians, the ability to manipulate gene expression in a targeted manner is invaluable. These cell lines provide an unparalleled opportunity to deepen our understanding of gene function, paving the way for breakthroughs in diagnostics and therapeutics. With our commitment to advancing biological research, our company specializes in producing high-quality genetic models tailored to meet the rigorous needs of the scientific community, ensuring that you have access to the best resources for your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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