Gene: KDM1A
Official Full Name: lysine demethylase 1Aprovided by HGNC
Gene Summary: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00460 | KDM1A gRNA5-gRNA6 KO plasmid | KDM1A | $850 | |||
GP00461 | KDM1A gRNA1-gRNA2 KO plasmid | KDM1A | $850 | |||
KO00742 | KDM1A Knockout cell line (A549) | Human | KDM1A | 1:3~1:4 | Negative | Online Inquiry |
KO16794 | KDM1A Knockout cell line (HeLa) | Human | KDM1A | 1:3~1:6 | Negative | Online Inquiry |
KO16795 | KDM1A Knockout cell line (HEK293) | Human | KDM1A | 1:3~1:6 | Negative | Online Inquiry |
KO39171 | KDM1A Knockout cell line (HCT 116) | Human | KDM1A | 1:2~1:4 | Negative | Online Inquiry |
KDM1A Gene Knockout Cell Lines represent a specialized set of genetically modified cell lines where the KDM1A gene, known for its role in demethylating histones and influencing epigenetic regulation, has been effectively disrupted. This innovative product serves as a crucial tool for researchers investigating gene function, cellular differentiation, and various disease mechanisms, particularly in cancer and neurodegenerative disorders.
The primary function of KDM1A is to remove methyl groups from lysine 4 on histone H3, thereby facilitating gene expression changes crucial for cellular growth and remodeling. By utilizing these knockout cell lines, researchers can explore the consequences of KDM1A loss across diverse biological contexts, including senescence, apoptosis, and stem cell biology. The knockout lines allow scientists to investigate downstream effects on gene expression profiles, providing insights into the intricate regulatory networks that govern cellular behavior.
The scientific importance of KDM1A Gene Knockout Cell Lines extends to both basic and applied research, including drug discovery, cancer therapeutics, and developmental biology. In clinical settings, understanding the epigenetic modifications orchestrated by KDM1A is vital for developing innovative treatments targeting its dysregulation.
What sets KDM1A Gene Knockout Cell Lines apart from traditional models is their specificity and reliability. Unlike other systems that may introduce unintended genetic alterations, these knockout lines offer a clean and precise disruption of the target gene, ensuring high experimental fidelity. Additionally, the cell lines are validated for consistent performance, providing researchers with confidence in their results.
The value of KDM1A Gene Knockout Cell Lines lies in their ability to accelerate research by providing a robust platform for exploring gene function, identifying novel therapeutic targets, and simulating pathological conditions. By utilizing these cell lines, researchers can significantly enhance their understanding of complex biological processes, ultimately leading to advancements in disease treatments and innovative therapeutic strategies.
Our company prides itself on delivering high-quality biological products backed by extensive expertise in genetic engineering and cell line development. We are committed to supporting the scientific community with products that facilitate groundbreaking discoveries in molecular biology and translational medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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