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KCTD1 Knockout Cell Lines

Gene: KCTD1

Official Full Name: potassium channel tetramerization domain containing 1provided by HGNC

Gene Summary: This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16821 KCTD1 Knockout cell line (HeLa) Human KCTD1 1:3~1:6 Negative Online Inquiry
KO16822 KCTD1 Knockout cell line (HCT 116) Human KCTD1 1:2~1:4 Negative Online Inquiry
KO16823 KCTD1 Knockout cell line (HEK293) Human KCTD1 1:3~1:6 Negative Online Inquiry
KO16824 KCTD1 Knockout cell line (A549) Human KCTD1 1:3~1:4 Negative Online Inquiry

Background

KCTD1 Gene Knockout Cell Lines are genetically engineered cell models where the KCTD1 gene has been disrupted to study its biological function and involvement in various cellular processes. These knockout cell lines are pivotal for researchers aiming to elucidate the role of KCTD1 in cellular mechanisms, particularly those associated with cell proliferation, differentiation, and signal transduction pathways. The gene knockout mechanism is achieved through advanced techniques such as CRISPR/Cas9 or traditional homologous recombination, allowing the precise deletion of KCTD1, leading to the complete absence of its encoded protein.

The significance of KCTD1 knockout cell lines lies in their profound applications in both basic and applied research. By providing a platform to investigate the implications of KCTD1 deficiency, researchers can explore its potential link to diseases such as cancer and neurodegenerative disorders. Furthermore, these lines can be utilized to test therapeutic strategies aimed at modulating KCTD1-associated pathways, thereby rendering them invaluable for drug discovery and development.

Compared to alternative methods such as transient knockdown techniques, which often yield short-term effects and variability, KCTD1 gene knockout cell lines provide stable, long-lasting genetic modifications. This stability significantly enhances the reproducibility of experimental results and offers a more accurate depiction of the biological consequences of gene ablation.

For researchers and clinicians, the value of KCTD1 Gene Knockout Cell Lines extends beyond experimental convenience; it offers a deeper understanding of genetic contributions to disease pathology and therapeutic efficacy. Our company specializes in providing high-quality genetically modified cell lines, supported by a team of experts dedicated to advancing scientific research through innovative biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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