Home / KCNK9 Knockout Cell Lines

KCNK9 Knockout Cell Lines

Gene: KCNK9

Official Full Name: potassium two pore domain channel subfamily K member 9provided by HGNC

Gene Summary: This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22703 KCNK9 Knockout cell line (HCT 116) Human KCNK9 1:2~1:4 Negative Online Inquiry

Background

KCNK9 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the function of the KCNK9 gene, which encodes a potassium channel important for maintaining cellular homeostasis and excitability. This product provides researchers with a valuable tool to study the effects of KCNK9 disruption on various physiological and pathophysiological processes, particularly in neuronal and cardiac cells where potassium ion regulation is critical.

The primary function of these cell lines is to facilitate the analysis of KCNK9's role in ion transport and its implications in conditions such as epilepsy, cardiac arrhythmias, and other disorders linked to ionic imbalances. Utilizing CRISPR/Cas9 genome editing technology, these knockout cell lines exhibit a complete absence of KCNK9, allowing for the examination of altered signaling pathways and cellular responses. Researchers can conduct functional assays, electrophysiological studies, and molecular analyses to investigate the downstream effects of KCNK9 loss on cellular behavior.

The scientific significance of KCNK9 Gene Knockout Cell Lines lies in their potential applications in both basic research and translational studies. These cell lines can help elucidate the mechanisms underlying various diseases, inform drug discovery efforts, and aid in the development of targeted therapies. Moreover, KCNK9 knockout models can serve as a benchmark for evaluating the efficacy of pharmacological interventions aimed at modulating potassium channel function.

One of the notable advantages of using these knockout cell lines is their specificity, which allows researchers to isolate the effects of KCNK9 without the confounding influence of other potassium channels. This precision contrasts with traditional pharmacological approaches that are often less selective and can lead to ambiguous results. Additionally, our KCNK9 Gene Knockout Cell Lines are validated for consistent performance across multiple experimental conditions, ensuring reliability and reproducibility—two key considerations in high-quality research.

In summary, KCNK9 Gene Knockout Cell Lines represent a powerful resource for researchers seeking to deepen their understanding of potassium channel biology and its clinical implications. As a company committed to advancing scientific discovery, we specialize in providing high-quality biological products that support innovative research. Our expertise in cellular technologies ensures that you have access to tools that enhance your investigations and drive meaningful results in your field.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.