Gene: KCNF1
Official Full Name: potassium voltage-gated channel modifier subfamily F member 1provided by HGNC
Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily F. This gene is intronless and expressed in all tissues tested, including the heart, skeletal muscle, brain, kidney, and pancreas. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37002 | KCNF1 Knockout cell line (A549) | Human | KCNF1 | 1:3~1:4 | Negative | Online Inquiry |
KCNF1 Gene Knockout Cell Lines represent a significant breakthrough in molecular biology, specifically designed to facilitate the study of the KCNF1 gene and its associated protein functions. These genetically modified cell lines lack the KCNF1 gene, providing researchers with an unparalleled opportunity to investigate the gene's role in various biological processes, including cellular signaling pathways, ion channel activity, and implications in disease states such as cancer and neurological disorders.
The primary mechanism of action for KCNF1 knockout cell lines lies in their ability to silence the expression of the KCNF1 gene, thereby enabling the observation of downstream effects and compensation mechanisms in cellular processes. Researchers can employ techniques such as functional assays, transcriptomic analyses, and proteomic profiling to assess the impact of this knockout on ion channel functionality and cellular homeostasis. This adds a layer of understanding essential for elucidating the role of KCNF1 in pathophysiological contexts.
Scientifically, KCNF1 Gene Knockout Cell Lines are invaluable in both research and clinical settings, particularly for those investigating ion channel-related diseases or disorders linked to aberrant cellular signaling. Their availability allows biologists and pharmacologists to explore targeted therapeutic strategies, including the development of potassium channel inhibitors or activators.
Compared to other genetic manipulation techniques, such as CRISPR or RNA interference, these knockout cell lines offer a stable, ready-to-use system with consistent genetic expression profiles. This convenience enhances reproducibility and reduces variability often associated with transient knockdowns or gene editing, ultimately accelerating the pace of research.
For researchers and clinicians, the value of KCNF1 Gene Knockout Cell Lines is amplified by their ability to provide insights into potential drug targets and biomarkers. As experts in the field of genetic modeling, our company is committed to delivering high-quality, reliable products that pave the way for innovative scientific discoveries, empowering the next generation of research and therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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