Gene: KCND1
Official Full Name: potassium voltage-gated channel subfamily D member 1provided by HGNC
Gene Summary: This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36995 | KCND1 Knockout cell line (HCT 116) | Human | KCND1 | 1:2~1:4 | Negative | Online Inquiry |
KO36996 | KCND1 Knockout cell line (HEK293) | Human | KCND1 | 1:3~1:6 | Negative | Online Inquiry |
KCND1 Gene Knockout Cell Lines are specialized cell lines engineered for the targeted disruption of the KCND1 gene, which encodes for a voltage-gated potassium channel predominantly involved in neuronal excitability and various physiological processes. The precise knockout of this gene facilitates the in-depth investigation of its functional role in cellular physiology and pathology, making these cell lines an invaluable tool for researchers studying ion channel biology.
The primary function of KCND1 gene knockout cell lines is to enable scientists to observe the phenotypic and biochemical changes that occur in the absence of the KCND1 protein. This can be achieved through techniques such as electrophysiological assays to assess changes in membrane potential and action potential firing, alongside molecular characterization to evaluate downstream signaling pathways affected by KCND1 disruption. By elucidating the contributions of KCND1 to cellular functions, these cell lines aid in advancing our understanding of neurological disorders, arrhythmias, and other conditions linked to ion channel dysfunction.
In the context of scientific importance, KCND1 knockout models serve as critical assets in developmental biology, neurobiology, and pharmacology research. They provide researchers with the capability to identify potential therapeutic targets and foster the development of drugs that modulate KCND1 channel activity.
Compared to other gene knockout models, KCND1 gene knockout cell lines offer superior specificity and ease of use, as they have been optimized for high-throughput screening and are compatible with a range of cellular assays. This streamlined application not only reduces the time and resources traditionally required for knockout validation but also enriches experimental reproducibility and reliability.
For researchers and clinicians invested in the dynamics of neuronal signaling or ion channel-related disorders, the KCND1 gene knockout cell lines represent significant value. By leveraging these advanced models, scientists can unravel complex biological interactions and contribute to the development of innovative therapeutic strategies.
Our company specializes in providing high-quality genetic models and has a robust track record of supporting the scientific community with our expertise in gene editing technologies. With our commitment to advancement in biological research, our products, including KCND1 gene knockout cell lines, are designed to accelerate discovery and foster breakthroughs across various fields of study.
Please note that all services are for research use only. Not intended for any clinical use.
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