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KCNC1 Knockout Cell Lines

Gene: KCNC1

Official Full Name: potassium voltage-gated channel subfamily C member 1provided by HGNC

Gene Summary: This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36997 KCNC1 Knockout cell line (HEK293) Human KCNC1 1:3~1:6 Negative Online Inquiry

Background

KCNC1 Gene Knockout Cell Lines are specifically engineered cellular models that enable the functional study of the KCNC1 gene, which encodes for the voltage-gated potassium channel subunit Kv3.1. Through precise gene-editing techniques such as CRISPR-Cas9, these cell lines exhibit targeted disruptions of the KCNC1 gene, allowing researchers to investigate the physiological and pathological roles of Kv3.1 in cellular excitability and neuronal signaling.

The primary function of these cell lines is to elucidate the biochemical pathways and physiological consequences resulting from the absence of the KCNC1 gene. By utilizing these knockout models, scientists can assess the impacts on action potential firing rates, synaptic transmission, and overall cellular excitability. This mechanistic understanding is critical for revealing the contributions of Kv3.1 in neurophysiological processes and its implications in neurological disorders such as epilepsy, synaptic dysfunction, and developmental disorders.

From a scientific perspective, KCNC1 Gene Knockout Cell Lines represent a valuable tool in both research and clinical settings. They facilitate the study of various cellular responses to pharmacological agents, the dissection of signaling pathways, and the validation of potential therapeutic targets. Given their unique ability to model genetic knockout scenarios, these cell lines foster innovation in drug discovery and genetic research, thereby advancing our understanding of underlying disease mechanisms.

Compared to traditional cell lines or transgenic models, the advantages of KCNC1 knockout cell lines include the precision of gene editing, resulting in a more accurate representation of the impact of gene loss. This specificity enables researchers to derive clearer conclusions from experimental data and facilitates reproducibility across studies. Furthermore, these cell lines are readily available and can be easily integrated into existing experimental workflows.

Researchers and clinicians will find the KCNC1 Gene Knockout Cell Lines invaluable as they bridge the gap between basic scientific research and clinical application. By enhancing the understanding of potassium channel functions, this product bears the potential to contribute to the development of novel therapeutic strategies.

Our company brings extensive experience in genetic engineering and cell line development, ensuring that our products are of the highest quality and reliability. With a commitment to advancing scientific discovery, we continuously strive to provide innovative solutions that empower researchers and clinicians in their quest for knowledge and therapeutic breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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