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KBTBD8 Knockout Cell Lines

Gene: KBTBD8

Official Full Name: kelch repeat and BTB domain containing 8provided by HGNC

Gene Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in neural crest cell development; neural crest formation; and protein monoubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06412 KBTBD8 Knockout cell line (HeLa) Human KBTBD8 1:3~1:6 Negative Online Inquiry
KO06413 KBTBD8 Knockout cell line (HCT 116) Human KBTBD8 1:2~1:4 Negative Online Inquiry
KO06414 KBTBD8 Knockout cell line (HEK293) Human KBTBD8 1:3~1:6 Negative Online Inquiry
KO06415 KBTBD8 Knockout cell line (A549) Human KBTBD8 1:3~1:4 Negative Online Inquiry

Background

KBTBD8 Gene Knockout Cell Lines are genetically engineered cell lines that specifically target the KBTBD8 gene, a crucial component in various cellular processes including protein degradation, cell signaling, and cellular response to stress. These knockout cell lines have been meticulously developed using CRISPR-Cas9 gene editing technology, allowing for the precise deletion of the KBTBD8 gene and thereby creating a model system that facilitates the study of gene function and regulation in a controlled environment.

The primary mechanism through which KBTBD8 knockout cell lines operate is the absence of the KBTBD8 protein, which impacts cellular behaviors such as proliferation, apoptosis, and differentiation. Researchers utilize these cell lines to investigate the gene's role in various biological pathways, elucidate its implications in diseases such as cancer and neurodegenerative disorders, and evaluate cell responses to pharmacological agents. This makes KBTBD8 knockout cell lines invaluable for both fundamental and applied biomedical research.

In both research and clinical settings, these cell lines stand out due to their specificity and reliability compared to alternative models, such as transient transfection or conventional knockout methodologies, which may lack consistency. Researchers benefit from the stable genetic modification that allows for long-term studies and multiple experimental replicates, increasing the reliability and validity of results. Furthermore, these cell lines are compatible with a variety of assays, including pharmacology, gene expression analysis, and protein interaction studies.

The use of KBTBD8 knockout cell lines enriches any laboratory's investigative capabilities, offering profound insights into cellular mechanisms and potential therapeutic interventions. This product is a testament to our commitment to advancing genetic research, as our company possesses extensive expertise in developing high-quality biological research tools that empower scientists worldwide in their quest for innovation and discovery in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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