Gene: KBTBD3
Official Full Name: kelch repeat and BTB domain containing 3provided by HGNC
Gene Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24153 | KBTBD3 Knockout cell line (HeLa) | Human | KBTBD3 | 1:3~1:6 | Negative | Online Inquiry |
KO24154 | KBTBD3 Knockout cell line (HCT 116) | Human | KBTBD3 | 1:2~1:4 | Negative | Online Inquiry |
KO24155 | KBTBD3 Knockout cell line (A549) | Human | KBTBD3 | 1:3~1:4 | Negative | Online Inquiry |
KBTBD3 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the investigation of KBTBD3 function in various biological processes. These cell lines are generated through advanced CRISPR/Cas9 gene-editing technology, allowing for the precise disruption of the KBTBD3 gene, which is known to play a role in cellular signaling, mitotic regulation, and protein degradation pathways. By creating these knockout models, researchers can study the phenotypic and molecular effects of KBTBD3 deficiency, thereby elucidating its role in cellular behaviors such as proliferation, apoptosis, and stress response.
The key mechanism employed in producing KBTBD3 knockout cell lines involves the targeted introduction of DNA double-strand breaks at specific genomic locations, followed by the cell's natural repair processes that lead to the insertion or deletion of nucleotides, effectively leading to gene inactivation. This level of precision offers a robust platform for gene function studies, drug screening, and biomarker discovery.
The scientific importance of KBTBD3 knockout cell lines cannot be overstated, as they serve as crucial tools in both basic research and clinical applications, including cancer research, where KBTBD3 has been implicated in tumorigenesis and metastasis. By understanding the functional contributions of KBTBD3 in disease contexts, researchers can pave the way for potential therapeutic interventions aimed at modulating its activity.
Compared to alternative models, KBTBD3 knockout cell lines provide several unique advantages, including their specificity for KBTBD3, reproducibility, and ease of use in experimental setups. They are ideal for a wide range of assays, including CRISPR validation studies and drug response assessments that require precise genetic backgrounds.
For researchers and clinicians aiming to deepen their understanding of KBTBD3-related pathways, these knockout cell lines represent an invaluable resource, driving innovations in therapeutic strategies and improving patient outcomes. Our company is committed to delivering high-quality biological products backed by extensive expertise in genetic engineering and cell line development, ensuring reliable models that meet the rigorous demands of modern scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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