Gene: KATNB1
Official Full Name: katanin regulatory subunit B1provided by HGNC
Gene Summary: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32004 | KATNB1 Knockout cell line (HeLa) | Human | KATNB1 | 1:3~1:6 | Negative | Online Inquiry |
KO32005 | KATNB1 Knockout cell line (HCT 116) | Human | KATNB1 | 1:2~1:4 | Negative | Online Inquiry |
KO32006 | KATNB1 Knockout cell line (HEK293) | Human | KATNB1 | 1:3~1:6 | Negative | Online Inquiry |
KO32007 | KATNB1 Knockout cell line (A549) | Human | KATNB1 | 1:3~1:4 | Negative | Online Inquiry |
KATNB1 Gene Knockout Cell Lines are advanced cellular models engineered to specifically disable the KATNB1 gene, which encodes for the Katanin p60 subunit involved in microtubule severing and cellular dynamics. This product provides a crucial tool for researchers investigating the roles of KATNB1 in cellular processes, such as mitosis, wound healing, and intracellular transport. By knocking out this gene, researchers can observe the consequent physiological and molecular changes, enabling in-depth studies of microtubule regulation and its broader implications in cell biology.
The primary mechanism at play involves the disruption of normal microtubule function, allowing for the evaluation of cellular behavior in the absence of KATNB1. This disruption can lead to alterations in cell morphology, division rates, and intracellular signaling pathways, providing a wealth of data for studies related to cancer, neurodegenerative diseases, and other conditions where microtubule dynamics play a critical role.
The scientific importance and applications of KATNB1 Gene Knockout Cell Lines extend into both research and clinical settings, serving as vital models for drug discovery and the development of therapeutic strategies. They offer unique insights into microtubule-targeting therapies and genetic interactions within varied cellular environments.
One of the distinct advantages of KATNB1 Gene Knockout Cell Lines is their specificity and reproducibility, which often outperforms conventional methods of gene silencing, such as RNA interference. Researchers can achieve a complete knockout, ensuring that the effects observed are solely due to the absence of KATNB1. This level of control is essential for obtaining reliable data.
For researchers and clinicians focused on understanding microtubule dynamics and developing innovative treatments, the value of KATNB1 Gene Knockout Cell Lines is profound. They facilitate breakthrough discoveries and accelerate the translation of laboratory findings into clinical applications.
As a leader in the development of innovative biological models, our company is committed to providing high-quality, expertly crafted products that empower scientific inquiry and contribute to the advancement of biomedical research. Our KATNB1 Gene Knockout Cell Lines are a testament to our dedication to excellence in the life sciences arena.
Please note that all services are for research use only. Not intended for any clinical use.
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