Gene: JRK
Official Full Name: Jrk helix-turn-helix proteinprovided by HGNC
Gene Summary: This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33993 | JRK Knockout cell line (HeLa) | Human | JRK | 1:3~1:6 | Negative | Online Inquiry |
KO33994 | JRK Knockout cell line (HCT 116) | Human | JRK | 1:2~1:4 | Negative | Online Inquiry |
KO33995 | JRK Knockout cell line (HEK293) | Human | JRK | 1:3~1:6 | Negative | Online Inquiry |
KO33996 | JRK Knockout cell line (A549) | Human | JRK | 1:3~1:4 | Negative | Online Inquiry |
JRK Gene Knockout Cell Lines are a specialized suite of genetically engineered cell lines designed to facilitate the study of gene function, signaling pathways, and disease mechanisms. By employing advanced CRISPR/Cas9 technology, these cell lines have been meticulously crafted to introduce site-specific deletions of targeted genes, effectively producing loss-of-function models that researchers can use to dissect biological processes and assess gene involvement in various cellular contexts.
The primary mechanism of action behind the JRK Gene Knockout Cell Lines is the application of CRISPR-mediated gene editing, which allows for precise modifications at the genomic level. This technique is followed by validation through sequencing and phenotypic assays, ensuring that the resulting knockout is both efficient and functionally relevant. Such high fidelity in gene editing not only enhances the reproducibility of experiments but also increases reliability in downstream applications such as drug discovery, biological research, and genetic validation studies.
The scientific importance of JRK Gene Knockout Cell Lines is profound, particularly in the exploration of genetic contributions to disease states and the identification of potential therapeutic targets. These cell lines serve as invaluable platforms for research in cancer biology, neurobiology, and metabolic disorders, enabling scientists to conduct controlled experiments that elucidate the role of specific genes in pathogenesis or cellular response.
Compared to other gene knockout methodologies, the JRK Gene Knockout Cell Lines stand out due to their streamlined generation process and enhanced editing efficiency. Many traditional methods require labor-intensive procedures and lengthy timelines; in contrast, our cell lines provide ready-to-use models that save researchers time and increase experimental throughput.
For researchers and clinicians looking to delve deeper into genetic mechanisms, the JRK Gene Knockout Cell Lines offer unparalleled value by enabling more effective and innovative approaches to experimental design. The pre-established nature of these models allows for quicker hypothesis testing and validation, streamlining the pathway from discovery to application in clinical settings.
As a leader in biotechnology with years of experience in providing high-quality biological products, our commitment to scientific excellence and innovation positions us as a trusted partner for researchers and clinicians alike, equipping them with the tools necessary for groundbreaking discoveries and advancements in medical research.
Please note that all services are for research use only. Not intended for any clinical use.
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