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ITSN1 Knockout Cell Lines

Gene: ITSN1

Official Full Name: intersectin 1provided by HGNC

Gene Summary: The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35453 ITSN1 Knockout cell line (HeLa) Human ITSN1 1:3~1:6 Negative Online Inquiry
KO35454 ITSN1 Knockout cell line (HCT 116) Human ITSN1 1:2~1:4 Negative Online Inquiry
KO35455 ITSN1 Knockout cell line (HEK293) Human ITSN1 1:3~1:6 Negative Online Inquiry
KO35456 ITSN1 Knockout cell line (A549) Human ITSN1 1:3~1:4 Negative Online Inquiry

Background

ITSN1 Gene Knockout Cell Lines are specifically engineered cellular models that enable the study of the ITSN1 gene's role in various biological processes. These knockout cell lines have been created through precise gene editing techniques, such as CRISPR/Cas9, effectively disrupting the ITSN1 gene and allowing researchers to investigate the functional consequences of this gene's absence. The ITSN1 gene is known to play a pivotal role in endocytosis and signal transduction, essential processes in cellular communication and nutrient uptake.

The mechanism of the ITSN1 knockout involves the targeted disruption of the gene's coding sequence, leading to the complete loss of ITSN1 protein expression in these cells. As a result, researchers can study the phenotypic changes associated with ITSN1 deficiency, including alterations in cellular growth, migration, and responsiveness to external stimuli. This is particularly relevant for studies focusing on neurodegenerative diseases, cancer, and metabolic disorders, where ITSN1's function is critical.

The scientific importance of ITSN1 Gene Knockout Cell Lines is underscored by their broad applications in both research and clinical settings. They serve as valuable tools for elucidating the molecular mechanisms underlying various diseases and for identifying potential therapeutic targets. Furthermore, they facilitate the testing of drug candidates and the evaluation of new treatment strategies, enhancing the translational potential of basic research findings.

One significant advantage of using ITSN1 Gene Knockout Cell Lines is their specificity and reproducibility. Unlike traditional methods that may involve complex animal models, these cell lines offer a controlled environment allowing for precise manipulation and observation of cellular behavior. Additionally, they provide consistent results across experiments, which is crucial for generating reliable data.

For researchers and clinicians alike, the ITSN1 Gene Knockout Cell Lines present an invaluable resource for advancing our understanding of fundamental biological processes and their implications in health and disease. By utilizing these models, users can significantly enhance the quality of their research outcomes and potential clinical applications.

Our company specializes in high-quality genetic models and biological products tailored to meet the needs of the scientific community. With rigorous development and validation processes, we are committed to providing researchers with the tools necessary to push the boundaries of biological research and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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