Gene: ITGA1
Official Full Name: integrin subunit alpha 1provided by HGNC
Gene Summary: This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10321 | ITGA1 Knockout cell line (HeLa) | Human | ITGA1 | 1:3~1:6 | Negative | Online Inquiry |
KO10322 | ITGA1 Knockout cell line (HCT 116) | Human | ITGA1 | 1:2~1:4 | Negative | Online Inquiry |
KO10323 | ITGA1 Knockout cell line (A549) | Human | ITGA1 | 1:3~1:4 | Negative | Online Inquiry |
ITGA1 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of integrin alpha-1 (ITGA1) function within a biological context. These cell lines are generated through advanced CRISPR-Cas9 gene-editing technology, which proficiently disrupts the ITGA1 gene, effectively eliminating its expression. The ITGA1 protein plays a crucial role in cell adhesion, migration, and signaling, thus impacting various physiological processes including tissue regeneration and immune response.
The primary function of these knockout cell lines is to enable researchers to investigate the implications of ITGA1 loss on cellular behavior, interaction with extracellular matrix (ECM) components, and overall tissue dynamics. By manipulating the presence of ITGA1, scientists can elucidate its role in diseases such as fibrosis, cancer metastasis, and inflammatory disorders. These models serve as vital tools in both basic research and drug development pipelines, allowing for the identification of new therapeutic targets and validation of potential treatments.
The unique selling points of ITGA1 Gene Knockout Cell Lines include their high specificity and reproducibility, as well as the ability to provide insights that traditional models may not yield. Unlike alternative models, these knockout lines offer a direct observation of phenotypic changes associated with the absence of a specific gene, leading to more reliable data. Additionally, the use of these cell lines can significantly reduce time and resource expenditure in preclinical studies.
Researchers and clinicians benefit from these knockout models by acquiring a clearer understanding of diseases at the molecular level, ultimately driving innovation in therapeutic strategies. Our company brings years of experience in cellular engineering and molecular biology, ensuring that our products are meticulously validated and optimized for maximum performance in research applications. Embrace the power of ITGA1 Gene Knockout Cell Lines to advance your scientific inquiries and therapeutic developments.
Please note that all services are for research use only. Not intended for any clinical use.
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