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IRX5 Knockout Cell Lines

Gene: IRX5

Official Full Name: iroquois homeobox 5provided by HGNC

Gene Summary: This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32057 IRX5 Knockout cell line (HeLa) Human IRX5 1:3~1:6 Negative Online Inquiry
KO32058 IRX5 Knockout cell line (HEK293) Human IRX5 1:3~1:6 Negative Online Inquiry

Background

IRX5 Gene Knockout Cell Lines are specialized cellular systems engineered to contain a specific deletion of the IRX5 gene, which is part of the Iroquois homeobox gene family known for its critical role in regulating developmental processes and cellular differentiation. These knockout cell lines provide a powerful tool for studying the functional implications of IRX5 deficiency in various biological contexts, particularly in cancer research and developmental biology.

The key functionality of IRX5 Gene Knockout Cell Lines lies in their ability to elucidate the gene's role in cellular pathways. By completely disrupting the gene’s function, researchers can observe the resultant phenotypic changes and biochemical pathways that are affected. This mechanism allows scientists to explore how IRX5 contributes to processes such as embryonic development, tissue regeneration, and tumorigenesis, thus providing unprecedented insights into gene function and its interplay with various signaling networks.

The scientific importance of these cell lines is underscored by their diverse applications across both research and clinical settings. In the realm of cancer research, for instance, these cell lines can facilitate the examination of tumorigenic mechanisms and the identification of novel therapeutic targets that could arise from aberrant IRX5 signaling. Furthermore, they can serve as models for studying congenital malformations and other genetic disorders linked with developmental anomalies.

One specific advantage of using IRX5 Gene Knockout Cell Lines over traditional methods is their specificity and reliability in demonstrating functional outcomes directly associated with the gene. Unlike transient transfection methods, which may yield inconsistent results, these stable cell lines offer reproducibility and a consistent background for understanding the potential consequences of gene knockout. Additionally, their availability can significantly expedite the research timeline by providing an established framework for experimental design.

For researchers and clinicians grappling with the complexities of gene function and its implications for disease, IRX5 Gene Knockout Cell Lines represent a valuable asset. They empower users not only to investigate the intricacies of genetic regulation but also to translate these findings into potential interventions and therapeutic strategies.

With our extensive expertise in genetic engineering and commitment to providing high-quality biological products, our company ensures that each of our IRX5 Gene Knockout Cell Lines meets rigorous standards of performance and reliability, thus enhancing your research capabilities in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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