Home / IRAG1 Knockout Cell Lines

IRAG1 Knockout Cell Lines

Gene: IRAG1

Official Full Name: inositol 1,4,5-triphosphate receptor associated 1provided by HGNC

Gene Summary: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07494 IRAG1 Knockout cell line (HCT 116) Human IRAG1 1:2~1:4 Negative Online Inquiry

Background

IRAG1 Gene Knockout Cell Lines are specialized cell lines in which the IRAG1 gene has been entirely inactivated through targeted gene editing techniques, typically CRISPR-Cas9. This innovative tool allows researchers to study the specific biological roles of the IRAG1 gene, which is implicated in various signaling pathways affecting vascular smooth muscle function and immune response modulation. The mechanism of action involves the complete abrogation of IRAG1 expression, leading to observable phenotypic changes that can be rigorously quantified.

The scientific importance of these cell lines cannot be overstated. IRAG1 plays a critical role in nitric oxide signaling, which is essential for cardiovascular health. Understanding the functional implications of IRAG1 deletion allows researchers to dissect its contributions to pathological conditions such as hypertension and atherosclerosis. Additionally, these knockout models offer invaluable insights into immune system regulation, potentially informing therapeutic strategies for diseases characterized by dysregulated immune responses.

One of the standout advantages of using IRAG1 Gene Knockout Cell Lines is their ability to replicate human-specific biological responses, which provides a more relevant framework for experimentation compared to traditional animal models. This specificity enables more reliable translation of findings into clinical applications, reducing the gap between laboratory discovery and therapeutic innovation.

For researchers and clinicians alike, the purchase of these cell lines means access to a reliable and reproducible system for investigating the intricate roles of IRAG1 in disease, as well as a platform for testing potential therapeutics. Furthermore, our company is dedicated to advancing scientific research by providing high-quality biological products. With rigorous quality control and expert support, our offerings empower the scientific community to make groundbreaking discoveries with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.