Gene: INTS6
Official Full Name: integrator complex subunit 6provided by HGNC
Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28074 | INTS6 Knockout cell line (HeLa) | Human | INTS6 | 1:3~1:6 | Negative | Online Inquiry |
KO28075 | INTS6 Knockout cell line (HCT 116) | Human | INTS6 | 1:2~1:4 | Negative | Online Inquiry |
KO28076 | INTS6 Knockout cell line (HEK293) | Human | INTS6 | 1:3~1:6 | Negative | Online Inquiry |
INTS6 Gene Knockout Cell Lines are advanced biological research tools specifically designed for the investigation of the INTS6 gene, which is integral in various cellular processes, including translation regulation, cell growth, and stress response. These cell lines have been engineered using CRISPR/Cas9 technology to create precise disruptions in the INTS6 gene, enabling researchers to analyze the resulting phenotypic changes and gain insights into the gene’s role in health and disease.
The INTS6 gene plays a crucial role in the integrity of the cellular ribonucleoprotein complex and has been linked to cancer progression and treatment resistance. By utilizing these knockout cell lines, scientists can dissect the molecular pathways affected by INTS6 absence, explore potential therapeutic targets, and understand the gene's contributions in oncogenesis. This tool is particularly vital for elucidating the mechanisms behind diseases and for testing novel therapeutic strategies in a controlled environment.
What sets INTS6 Gene Knockout Cell Lines apart from alternative models is the precision and efficiency with which these lines have been developed. The use of CRISPR/Cas9 ensures that the knockout is specific and reproducible, reducing off-target effects commonly associated with other gene disruption methods. Additionally, these cell lines are validated for consistent performance, providing researchers with reliable data essential for their studies.
The value of INTS6 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to offer insights into complex biological questions, ultimately assisting in the development of therapeutic interventions. The targeted application of INTS6 in studying critical disease mechanisms makes this product an invaluable resource in both academic and clinical research settings.
Our company specializes in providing high-quality, innovative biological products tailored for advanced scientific research. With a robust background in genetic engineering and a commitment to excellence, we equip researchers with the tools necessary to drive groundbreaking discoveries in molecular biology and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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