Gene: INPP5J
Official Full Name: inositol polyphosphate-5-phosphatase Jprovided by HGNC
Gene Summary: Predicted to enable inositol trisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in negative regulation of microtubule polymerization. Predicted to act upstream of or within negative regulation of neuron projection development and negative regulation of peptidyl-serine phosphorylation. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27818 | INPP5J Knockout cell line (HeLa) | Human | INPP5J | 1:3~1:6 | Negative | Online Inquiry |
KO27819 | INPP5J Knockout cell line (HCT 116) | Human | INPP5J | 1:2~1:4 | Negative | Online Inquiry |
KO27820 | INPP5J Knockout cell line (HEK293) | Human | INPP5J | 1:3~1:6 | Negative | Online Inquiry |
KO27821 | INPP5J Knockout cell line (A549) | Human | INPP5J | 1:3~1:4 | Negative | Online Inquiry |
INPP5J Gene Knockout Cell Lines are highly specialized biological products designed to facilitate the study of the inositol polyphosphate pathway and its implications in cellular signaling. By utilizing CRISPR-Cas9 gene editing technology, these cell lines have been engineered to disrupt the INPP5J gene, leading to a complete knockout of its expression. This disruption allows researchers to investigate the physiological roles and potential pathophysiological implications of INPP5J in various biological contexts, including cancer biology, metabolic disorders, and neurodegenerative diseases.
The key functions of INPP5J involve modulating intracellular signaling pathways through the dephosphorylation of inositol phosphate molecules. By eliminating its activity, researchers can elucidate pathways influenced by phosphoinositides, which play critical roles in cellular processes such as migration, proliferation, and apoptosis. This gene knockout model is pivotal in delineating the functional contribution of INPP5J to cellular behavior, providing insights into its role as a potential therapeutic target.
This product holds significant importance in both research and clinical settings. Using INPP5J knockout cell lines offers valuable tools for drug screening, genetic studies, and the exploration of disease mechanisms. Importantly, they allow for the validation of hypotheses related to drug efficacy and the exploration of novel therapeutic strategies targeting the inositol signaling pathway.
Among the advantages of our INPP5J Gene Knockout Cell Lines is the precision of the gene editing approach, which ensures a complete and specific gene disruption with minimal off-target effects. This level of specificity enhances the reliability of experimental results, making these cell lines more advantageous compared to traditional knockout models. Moreover, they provide a reproducible and standard platform for comparative studies, allowing researchers to accelerate their findings in cell biology.
In conclusion, the INPP5J Gene Knockout Cell Lines represent a critical resource for researchers and clinicians aiming to deepen their understanding of cellular mechanisms and explore new avenues for treatment. Our company's commitment to cutting-edge genetic solutions ensures that we offer not only advanced products but also exceptional expertise and support to our users, empowering them to advance their research effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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