Gene: INPP5B
Official Full Name: inositol polyphosphate-5-phosphatase Bprovided by HGNC
Gene Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07915 | INPP5B Knockout cell line (HeLa) | Human | INPP5B | 1:3~1:6 | Negative | Online Inquiry |
KO07916 | INPP5B Knockout cell line (HCT 116) | Human | INPP5B | 1:2~1:4 | Negative | Online Inquiry |
KO07917 | INPP5B Knockout cell line (HEK293) | Human | INPP5B | 1:3~1:6 | Negative | Online Inquiry |
KO07918 | INPP5B Knockout cell line (A549) | Human | INPP5B | 1:3~1:4 | Negative | Online Inquiry |
INPP5B Gene Knockout Cell Lines are specialized cellular models engineered to lack the inositol polyphosphate-5-phosphatase B gene (INPP5B), which plays a critical role in cellular signaling pathways by regulating phosphoinositide metabolism. These knockout cell lines enable researchers to study the functional consequences of INPP5B loss, particularly in the context of phosphoinositide signaling, which is integral to various cellular processes such as cell proliferation, differentiation, and apoptosis.
By utilizing these cell lines, scientists can investigate the specific mechanisms by which INPP5B influences cellular functions, including autophagy and immune response, thus providing insights into the pathophysiology of diseases linked to dysregulated signaling, such as cancer and neurodegenerative disorders. The INPP5B Gene Knockout Cell Lines serve as an invaluable tool in both basic and applied research settings, allowing for high-throughput screening and the validation of novel therapeutic targets.
One of the significant advantages of these knockout models is their specificity; unlike other methods of gene editing which may result in off-target effects, these cell lines provide a clean and consistent genetic background, ensuring that observed phenotypic changes can be directly attributed to the absence of INPP5B. Furthermore, they are readily adaptable for a range of assays, including drug response studies and signaling pathway analysis, offering flexibility and utility that surpasses that of standard cell lines.
For researchers and clinicians aiming to delve deeper into the complexities of phosphoinositide signaling and its implications in human health and disease, the INPP5B Gene Knockout Cell Lines are a critical resource. They empower scientific investigation by allowing for precise manipulation of cellular pathways, ultimately advancing our understanding and treatment of various conditions.
Our company specializes in the development of high-quality biological products tailored for research applications. With a commitment to scientific rigor and innovation, we provide unparalleled support in optimizing cell line models that facilitate breakthrough discoveries in biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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