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INPP4B Knockout Cell Lines

Gene: INPP4B

Official Full Name: inositol polyphosphate-4-phosphatase type II Bprovided by HGNC

Gene Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09680 INPP4B Knockout cell line (HeLa) Human INPP4B 1:3~1:6 Negative Online Inquiry
KO09681 INPP4B Knockout cell line (HCT 116) Human INPP4B 1:2~1:4 Negative Online Inquiry
KO09682 INPP4B Knockout cell line (HEK293) Human INPP4B 1:3~1:6 Negative Online Inquiry
KO09683 INPP4B Knockout cell line (A549) Human INPP4B 1:3~1:4 Negative Online Inquiry

Background

INPP4B Gene Knockout Cell Lines represent a cutting-edge tool for researchers studying the biological roles of the INPP4B gene and its implications in various cellular processes. These specifically engineered cell lines have undergone targeted genome editing to eliminate the expression of INPP4B, a phosphoinositide 5-phosphatase that plays a crucial role in the regulation of phosphatidylinositol signaling pathways. By knocking out this gene, researchers can investigate its impact on cellular functions such as cell growth, proliferation, and apoptosis, providing invaluable insights into its contributions to cancer biology and other diseases.

The primary mechanism of action involves the complete inactivation of INPP4B, allowing for comparative studies between wild-type and knockout cells. This creates a controlled environment to elucidate the downstream effects of disrupted signaling pathways, particularly in the context of mTOR pathway regulation and its associations with oncogenesis. The INPP4B Knockout Cell Lines facilitate high-throughput screening, molecular signaling studies, and verification of potential therapeutic targets, enhancing the scope of experimental designs in basic and applied research.

Scientific importance is underscored by the association of INPP4B with various pathologies, including breast cancer and other malignancies, highlighting its potential as a biomarker or therapeutic target. The unique selling points of our INPP4B Gene Knockout Cell Lines include their reliability, reproducibility, and the comprehensive validation process they undergo to ensure consistent gene editing efficiency. This positions them as superior alternatives to traditional RNAi or CRISPR-based approaches, which may not achieve complete knockout or can introduce off-target effects.

For researchers and clinicians aiming for deeper understanding of INPP4B's biological functions, our knockout cell lines provide an essential resource. Utilizing these tools, you can significantly enhance the depth and quality of your research, leading to novel insights and potential therapeutic interventions. With years of expertise in the field of gene editing and a commitment to advancing research methodologies, our company offers high-quality biological products designed to accelerate scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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