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ILKAP Knockout Cell Lines

Gene: ILKAP

Official Full Name: ILK associated serine/threonine phosphataseprovided by HGNC

Gene Summary: The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25848 ILKAP Knockout cell line (HeLa) Human ILKAP 1:3~1:6 Negative Online Inquiry
KO25849 ILKAP Knockout cell line (HCT 116) Human ILKAP 1:2~1:4 Negative Online Inquiry
KO25850 ILKAP Knockout cell line (HEK293) Human ILKAP 1:3~1:6 Negative Online Inquiry
KO25851 ILKAP Knockout cell line (A549) Human ILKAP 1:3~1:4 Negative Online Inquiry

Background

ILKAP Gene Knockout Cell Lines are genetically modified cell lines crafted to provide researchers with a robust tool for studying the role of the ILKAP gene, a critical component in various signaling pathways involved in cellular growth and differentiation. These cell lines are generated using precise CRISPR/Cas9 technology, allowing for the specific and efficient disruption of the ILKAP gene. By creating a knockout model, researchers can observe the resultant phenotypic changes and assess the gene's functional implications in cellular processes.

The primary function of ILKAP Gene Knockout Cell Lines is to enable detailed investigations into ILKAP's involvement in cellular responses, such as stress signaling and apoptosis. The mechanisms of action can be analyzed through a series of downstream effects, enabling researchers to elucidate how ILKAP regulates key signaling pathways, including those involved in cancer progression and resistance to therapies. Moreover, these knockout models are crucial for the development of targeted therapeutic strategies in clinical settings, where understanding gene functionality can lead to personalized medicine approaches.

Compared to traditional gene knockdown methods, such as siRNA or shRNA, knockout cell lines offer the distinct advantage of permanently disrupting the gene of interest, providing a more stable and reliable system for long-term studies. This allows for the analysis of chronic effects on cell behavior and signaling dynamics that short-term knockdowns cannot achieve. Furthermore, the specificity of CRISPR/Cas9 minimizes off-target effects, increasing the confidence in experimental results.

These cell lines represent invaluable resources for researchers and clinicians looking to dissect ILKAP gene functions in both basic and applied biomedical research. By leveraging these models, scientists can contribute to the advancement of therapeutic developments in cancer and other diseases influenced by ILKAP signaling.

Our company prides itself on delivering high-quality biological products and has a proven track record in the field of genetic engineering. Our ILKAP Gene Knockout Cell Lines are backed by rigorous validation and are supported by our expertise in developing innovative research tools that empower scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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