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IBTK Knockout Cell Lines

Gene: IBTK

Official Full Name: inhibitor of Bruton tyrosine kinaseprovided by HGNC

Gene Summary: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28506 IBTK Knockout cell line (HeLa) Human IBTK 1:3~1:6 Negative Online Inquiry
KO28507 IBTK Knockout cell line (HCT 116) Human IBTK 1:2~1:4 Negative Online Inquiry
KO28508 IBTK Knockout cell line (HEK293) Human IBTK 1:3~1:6 Negative Online Inquiry
KO28509 IBTK Knockout cell line (A549) Human IBTK 1:3~1:4 Negative Online Inquiry

Background

IBTK Gene Knockout Cell Lines represent a sophisticated tool in molecular biology, specifically designed to facilitate the study of the IBTK gene's function by creating precise gene knockouts in a variety of cell types. Through the application of advanced CRISPR-Cas9 genome-editing technology, these cell lines effectively disable the IBTK gene, allowing researchers to observe the resultant phenotypic changes, thereby elucidating the gene's role in cellular processes such as cell proliferation, apoptosis, and stress response.

The mechanism underlying the use of IBTK Gene Knockout Cell Lines lies in their ability to provide insights into gene function through loss-of-function studies. By selectively knocking out the IBTK gene, researchers can investigate downstream signaling pathways and identify potential compensatory mechanisms that may occur due to gene disruption. This feature is crucial for understanding the genetic basis of diseases, particularly those related to cellular stress and tumorigenesis.

In research and clinical settings, the IBTK Gene Knockout Cell Lines hold substantial scientific importance, as they support the exploration of therapeutic targets in cancer biology and other diseases. By utilizing these cell lines, scientists can assess the impact of IBTK gene deletion on drug responses, thereby paving the way for developing more effective treatment strategies tailored to individual genetic profiles.

One of the primary advantages of our IBTK Gene Knockout Cell Lines is the streamlined selection process and confirmation of gene disruption, which can significantly reduce the time from experiment design to actionable results. Additionally, our products are uniquely validated for various research applications, ensuring consistency and reproducibility—key factors in experimental design.

For researchers and clinicians seeking to gain a deeper understanding of genetic influence on cellular functions, IBTK Gene Knockout Cell Lines offer an invaluable resource. They not only enhance the comprehension of IBTK’s implications in health and disease but also support the development of targeted therapies.

Our company is committed to providing high-quality biological products backed by rigorous scientific validation, ensuring that researchers have access to the best tools necessary for advancing their work. With our expertise and dedication to innovation, we strive to empower discoveries that lead to improved health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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