Gene: IBA57
Official Full Name: iron-sulfur cluster assembly factor IBA57provided by HGNC
Gene Summary: The protein encoded by this gene localizes to the mitochondrion and is part of the iron-sulfur cluster assembly pathway. The encoded protein functions late in the biosynthesis of mitochondrial 4Fe-4S proteins. Defects in this gene have been associated with autosomal recessive spastic paraplegia-74 and with multiple mitochondrial dysfunctions syndrome-3. Two transcript variants encoding different isoforms have been found for this gene. The smaller isoform is not likely to be localized to the mitochondrion since it lacks the amino-terminal transit peptide. [provided by RefSeq, Jul 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38288 | IBA57 Knockout cell line (HeLa) | Human | IBA57 | 1:3~1:6 | Negative | Online Inquiry |
KO38289 | IBA57 Knockout cell line (HCT 116) | Human | IBA57 | 1:2~1:4 | Negative | Online Inquiry |
KO38290 | IBA57 Knockout cell line (HEK293) | Human | IBA57 | 1:3~1:6 | Negative | Online Inquiry |
KO38291 | IBA57 Knockout cell line (A549) | Human | IBA57 | 1:3~1:4 | Negative | Online Inquiry |
IBA57 Gene Knockout Cell Lines represent a pioneering tool in the field of genomic research, specifically designed to facilitate the functional analysis of the IBA57 gene associated with mitochondrial biology and human health. These cell lines have been genetically engineered to disrupt the IBA57 gene, enabling researchers to investigate its role in various biological processes, including mitochondrial translation and overall cellular metabolism.
The key function of IBA57 is pivotal in the assembly and stability of mitochondrial complexes, which are essential for ATP production. By knocking out this gene, the resultant cell lines exhibit distinct phenotypes, allowing scientists to explore the resultant changes in metabolic pathways and mitochondrial function. This model system provides a robust platform for the study of mitochondrial diseases, drug discovery, and targeted therapeutic interventions, making it invaluable in both basic and applied biological research.
From a scientific standpoint, the availability of IBA57 Gene Knockout Cell Lines is critical for advancing our understanding of mitochondrial dysfunction and its implications in conditions such as neurodegenerative diseases and metabolic disorders. The specificity of these cell lines provides a more accurate model system than conventional methods, significantly enhancing the reliability of experimental outcomes.
In comparison to alternative products, IBA57 Gene Knockout Cell Lines offer unmatched precision in gene editing, validated experimental results, and ease of use, providing researchers with a powerful tool to dissect complex biological mechanisms. Additionally, these cell lines are compatible with various assays, allowing seamless integration into existing research workflows.
For researchers and clinicians focused on mitochondrial research, IBA57 Gene Knockout Cell Lines hold immense value as they pave the way for groundbreaking discoveries and potential therapeutic targets. Our company's extensive expertise in gene editing technologies ensures that you receive not just superior products, but also ongoing support and consultation to maximize your research efforts.
Please note that all services are for research use only. Not intended for any clinical use.
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