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HSF4 Knockout Cell Lines

Gene: HSF4

Official Full Name: heat shock transcription factor 4provided by HGNC

Gene Summary: Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00458 HSF4 Knockout cell line (A549) Human HSF4 1:3~1:4 Negative Online Inquiry
KO37173 HSF4 Knockout cell line (HeLa) Human HSF4 1:3~1:6 Negative Online Inquiry
KO37174 HSF4 Knockout cell line (HCT 116) Human HSF4 1:2~1:4 Negative Online Inquiry
KO37175 HSF4 Knockout cell line (HEK293) Human HSF4 1:3~1:6 Negative Online Inquiry

Background

HSF4 Gene Knockout Cell Lines are genetically engineered cellular models that have had the heat shock factor 4 (HSF4) gene specifically disrupted. HSF4 plays a crucial role in the regulation of the cellular response to stress, particularly under heat shock conditions, by modulating the expression of various heat shock proteins. These knockouts serve as invaluable tools for studying the intricate mechanisms of cellular stress responses and their implications in developmental biology, neuroprotection, and various diseases.

The primary function of HSF4 Gene Knockout Cell Lines lies in their ability to provide a controlled environment for researchers to observe the physiological and molecular changes associated with the absence of HSF4. By comparing these knockout lines to wild-type controls, scientists can elucidate the gene's role in cellular protection, apoptosis, and overall cell viability under stress conditions. The knockout model effectively uncovers the significance of HSF4 in cellular responses, providing insights that may lead to therapeutic approaches in conditions related to protein misfolding and aggregation.

In terms of scientific importance, HSF4 knockouts have broad applications in both fundamental research and clinical investigations. They enable the exploration of new drug targets and provide an experimental basis for understanding diseases linked to cellular stress, such as neurodegenerative disorders or cancers. These cell lines function as critical tools in drug screening assays, potentially leading to novel interventions that enhance cellular resilience.

Unique selling points of our HSF4 Gene Knockout Cell Lines include their high specificity, reproducibility, and the support of detailed characterization protocols provided by our team. Unlike alternative models, our products come backed with extensive validation data, ensuring optimal performance in your experimental designs.

The value of HSF4 Gene Knockout Cell Lines extends to researchers and clinicians alike, offering a pathway to innovative discoveries that can bridge the gap between basic research and therapeutic application. Our company prides itself on a commitment to excellence in the development of genetically modified cell lines, leveraging advanced biotechnology platforms and a deep understanding of cellular biology. With our expertise and dedication to research advancement, we provide unmatched product quality and support, ensuring your investigative efforts are met with success.

Please note that all services are for research use only. Not intended for any clinical use.

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