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HRH1 Knockout Cell Lines

Gene: HRH1

Official Full Name: histamine receptor H1provided by HGNC

Gene Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08076 HRH1 Knockout cell line (HeLa) Human HRH1 1:3~1:6 Negative Online Inquiry
KO08077 HRH1 Knockout cell line (HCT 116) Human HRH1 1:2~1:4 Negative Online Inquiry
KO08078 HRH1 Knockout cell line (A549) Human HRH1 1:3~1:4 Negative Online Inquiry

Background

HRH1 Gene Knockout Cell Lines are specialized cellular tools designed to study the histamine receptor H1 (HRH1) by disabling its genetic expression. These cell lines provide a valuable platform for researchers interested in the role of HRH1 in various physiological processes, including allergic responses, neurotransmission, and inflammation. By employing CRISPR-Cas9 technology, these knockout cell lines facilitate precise gene editing, ensuring that all aspects of HRH1 signaling can be thoroughly explored and understood.

The functionality of HRH1 Gene Knockout Cell Lines lies in their ability to provide a controlled environment where the absence of HRH1 can be observed. Researchers can utilize these lines to dissect the pathway mechanisms affected by histamine release and its evolution in tissues, leading to emerging insights into allergy management, asthma pathophysiology, and other receptor-related therapeutics. Notably, this model may uncover alternative signaling pathways activated during HRH1 loss, which can highlight new drug development targets.

From a scientific standpoint, the HRH1 Gene Knockout Cell Lines are essential for both basic and applied research in pharmacology and toxicology. Their applications in drug screening and validation enable clinicians and researchers to examine the efficacy of HRH1 antagonists and agonists accurately, paving the way for enhanced therapeutic strategies and personalized medicine approaches.

Compared to traditional cell lines or temporary knockdown methods, these knockout models offer unparalleled consistency, stability, and reproducibility in experiments. They eliminate the variability associated with transient transfection techniques while enabling long-term studies of the effects of HRH1 absence in various conditions.

Researchers and clinical practitioners will find immense value in these cell lines for their ability to facilitate innovative research and drive new discoveries in histamine receptor biology. Furthermore, they empower the scientific community to develop potent therapeutic agents targeting HRH1-mediated processes.

Our company prides itself on being at the forefront of genetic tool development and is committed to providing high-quality, rigorously validated biological products that meet the needs of researchers and clinicians alike. With a team of experts specializing in genetic engineering and molecular biology, we ensure our products offer reliable solutions tailored for advancing research in pharmacology and related fields.

Please note that all services are for research use only. Not intended for any clinical use.

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