Gene: HPF1
Official Full Name: histone PARylation factor 1provided by HGNC
Gene Summary: Enables chromatin binding activity; histone binding activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in DNA repair-dependent chromatin remodeling and double-strand break repair. Located in chromatin and nucleus. Is active in site of DNA damage. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17066 | HPF1 Knockout cell line (HeLa) | Human | HPF1 | 1:3~1:6 | Negative | Online Inquiry |
KO17067 | HPF1 Knockout cell line (HCT 116) | Human | HPF1 | 1:2~1:4 | Negative | Online Inquiry |
KO17068 | HPF1 Knockout cell line (HEK293) | Human | HPF1 | 1:3~1:6 | Negative | Online Inquiry |
KO17069 | HPF1 Knockout cell line (A549) | Human | HPF1 | 1:3~1:4 | Negative | Online Inquiry |
HPF1 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to eliminate the expression of the HPF1 gene, which plays a critical role in the cellular response to DNA damage and repair mechanisms. Utilizing advanced CRISPR-Cas9 gene-editing technology, these knockout cell lines provide a robust platform for studying the biological functions of HPF1, offering insights into its role in genomic stability, cell cycle regulation, and tumorigenesis.
The primary mechanism of action involves the targeted disruption of the HPF1 gene, which is integral to the repair of DNA double-strand breaks. When HPF1 is knocked out, researchers can analyze the resultant cellular responses, including changes in proliferation, apoptosis, and sensitivity to DNA-damaging agents. This real-time observation of cellular behavior under altered genetic conditions is invaluable for dissecting the pathways involved in cancer biology, neurodegenerative diseases, and other disorders linked to DNA repair deficiencies.
The scientific importance of HPF1 Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical development. For instance, they serve as crucial tools for testing new therapeutic strategies that target DNA repair mechanisms, making them essential in drug discovery and the development of personalized medicine approaches. Moreover, these cell lines enable researchers to explore the relationship between HPF1 dysfunction and various pathologies, fostering a deeper understanding of disease mechanisms.
One of the significant advantages of our HPF1 Gene Knockout Cell Lines is their high efficiency and specificity, ensuring that researchers obtain consistent and reproducible results. Furthermore, our product comes with comprehensive support and detailed documentation, empowering scientists with the resources they need to maximize their experiments' outcomes.
For researchers and clinicians, the value of HPF1 Gene Knockout Cell Lines lies not just in their experimental utility but also in the potential to unlock new therapeutic avenues. By utilizing these advanced cell lines, users can contribute to the ongoing efforts in understanding and combating diseases at a molecular level.
With decades of experience in creating innovative biological products, our company is dedicated to providing high-quality research tools that facilitate groundbreaking discoveries in molecular and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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